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Genetic Stability of Live Attenuated Vaccines Against Potentially Pandemic Influenza Viruses

Genetic stability is a prerequisite for live attenuated influenza vaccines (LAIVs). This article, published in Vaccine, reports the results of a Phase 1 study examining the stability of LAIVs against three potentially pandemic influenza viruses in healthy adults. The results showed high levels of vaccine virus genetic stability of the LAIV viruses recovered from immunized volunteers. In addition, no vaccine virus was detected in the placebo groups, indicating the lack of person-to-person transmission.

Author: Kiseleva I, Dubrovina I, Fedorova E, et al.

Published: 2015

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(Located at www.sciencedirect.com)

Citation: Kiseleva I, Dubrovina I, Fedorova E, et al. Genetic Stability of Live Attenuated Vaccines Against Potentially Pandemic Influenza Viruses. Vaccine. 2015;33(49):7008-7014.

Resource types: Peer-reviewed journal

Diseases/vaccines: Influenza

Topics: Vaccine safety and performance, Disease/vaccine specific information

Regions: Eastern Europe