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Development of a Stable Liquid Formulation of Live Attenuated Influenza Vaccine

Existing live attenuated seasonal influenza vaccines may require lyophilization to be stable enough for developing-country use, which adds a significant cost burden and reduces their use and accessibility in low-resource settings. This article, published in Vaccine, reports the results of a study to develop a low-cost, stable liquid formulation for a live attenuated seasonal influenza vaccine. The authors identified a liquid formulation that provided storage stability of one year at 2°C to 8°C for the influenza A and B strains tested.

Author: White JA, Estrada M, Flood EA, Mahmood K, Dhere R, Chen D

Published: 2016

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(Located at www.sciencedirect.com)

Citation: White JA, Estrada M, Flood EA, Mahmood K, Dhere R, Chen D. Development of a Stable Liquid Formulation of Live Attenuated Influenza Vaccine. Vaccine. 2016;34(32):3676-3683.

Resource types: Peer-reviewed journal

Diseases/vaccines: Influenza

Topics: Disease/vaccine specific information, Vaccine stabilization and formulation

Regions: Global