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Noninterference of Rotavirus Vaccine With Measles-Rubella Vaccine at 9 Months of Age and Improvements in Antirotavirus Immunity: A Randomized Trial

This article, published in the Journal of Infectious Diseases, presents the findings of a randomized trial in Matlab, Bangladesh that aimed to establish non-inferiority of the co-administration of measles-rubella vaccine and a third dose of monovalent human rotavirus vaccine, when compared to measles-rubella vaccine given alone. The study found that concomitant administration of a third dose of rotavirus vaccine had no negative effects on the immune responses to measles-rubella vaccine. Additionally, the study found that the third dose of rotavirus vaccine increased the anti-rotavirus immune response in infants relative to two doses of rotavirus vaccine.

Author: Zaman K, Fleming JA, Victor JC, et al.

Published: 2016

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(Located at jid.oxfordjournals.org)

Citation: Zaman K, Fleming JA, Victor JC, et al. Noninterference of Rotavirus Vaccine With Measles-Rubella Vaccine at 9 Months of Age and Improvements in Antirotavirus Immunity: A Randomized Trial. Journal of Infectious Diseases. 2016;213(11):1686-1693.

Resource types: Peer-reviewed journal

Diseases/vaccines: Rotavirus

Topics: Vaccine safety and performance, Disease/vaccine specific information

Regions: Asia