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Characterization of Mucosal Immune Responses to Enterotoxigenic Escherichia coli Vaccine Antigens in a Human Challenge Model: Response Profiles After Primary Infection and Homologous Rechallenge With Strain H10407

There is currently a poor understanding of the immune responses that correlate best with protection against enterotoxigenic Escherichia coli (ETEC) illness, which presents a challenge to vaccine development efforts. This article, published in Clinical and Vaccine Immunology, reports the results of a study that compared ETEC-specific mucosal immune responses in volunteers challenged with ETEC strain H10407 and volunteers rechallenged with the homologous organism. The authors anticipate that this study will help provide an immunological benchmark for the evaluation of ETEC vaccines and immunization regimens in the future.

Author: Chakraborty S, Harro C, DeNearing B, et al.

Published: 2016

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(Located at cvi.asm.org)

Citation: Chakraborty S, Harro C, DeNearing B, et al. Characterization of Mucosal Immune Responses to Enterotoxigenic Escherichia coli Vaccine Antigens in a Human Challenge Model: Response Profiles After Primary Infection and Homologous Rechallenge With Strain H10407. Clinical and Vaccine Immunology. 2016;23(1):55-64.

Resource types: Peer-reviewed journal

Diseases/vaccines: Shigellosis and enterotoxigenic Escherichia coli (ETEC)

Topics: Disease/vaccine specific information

Regions: Global