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Effect of Pentavalent Rotavirus Vaccine Introduction on Hospital Admissions for Diarrhoea and Rotavirus in Children in Rwanda: A Time-Series Analysis

This article, published in The Lancet Global Health, reports on the results of a time-series analysis that examined hospital admissions of children under five years of age due to diarrhea in Rwanda from 2009 to 2014. The authors compared hospital admissions for all-cause and rotavirus diarrhea before and after vaccine introduction. The results showed that, following the introduction of rotavirus vaccine into the routine national immunization program in 2012, hospital admissions for acute gastroenteritis decreased by about half (48 to 49 percent) and admissions specific to rotavirus declined by 61 to 70 percent. This paper provides the first evidence of indirect protection from rotavirus vaccination in a high-burden, low-income setting as well as the first data demonstrating the impact of routine pentavalent rotavirus vaccination in Africa.

Author: Ngabo F, Tate JE, Gatera M, et al.

Published: 2016

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(Located at www.thelancet.com)

Citation: Ngabo F, Tate JE, Gatera M, et al. Effect of Pentavalent Rotavirus Vaccine Introduction on Hospital Admissions for Diarrhoea and Rotavirus in Children in Rwanda: A Time-Series Analysis. The Lancet Global Health. 2016;4(2):e129-136.

Resource types: Peer-reviewed journal

Diseases/vaccines: Rotavirus

Topics: Disease burden and surveillance, Vaccine safety and performance, Disease/vaccine specific information

Regions: Africa