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Immunogenicity and Reactogenicity of Alternative Schedules of HPV Vaccine in Vietnam: A Cluster Randomized Noninferiority Trial

A potential barrier to human papillomavirus (HPV) vaccine introduction in low-resource countries is the three-dose schedule over a six-month period of time. This article, published in the Journal of the American Medical Association, describes the results of a study comparing two alternative dosing schedules (at 0, 3, and 9 months and at 0, 6, and 12 months) for the HPV vaccine with the standard schedule (at 0, 2, and 6 months) in Vietnam. The results showed that the antibody concentrations from the two alternative dosing schedules were not inferior to those from the standard schedule.

Author: Neuzil KM, Canh DG, Thiem VD, et al.

Published: 2011

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(Located at jama.jamanetwork.com)

Citation: Neuzil KM, Canh DG, Thiem VD, et al. Immunogenicity and Reactogenicity of Alternative Schedules of HPV Vaccine in Vietnam: A Cluster Randomized Noninferiority Trial. Journal of the American Medical Association. 2011;305(14):1424-1431. 

Resource types: Peer-reviewed journal

Diseases/vaccines: Human papillomavirus (HPV)

Topics: Vaccine safety and performance, Disease/vaccine specific information

Regions: Asia