PATH | VRL
Menu

Serum and Mucosal Antibody Responses to Inactivated Polio Vaccine After Sublingual Immunization Using a Thermoresponsive Gel Delivery System

This article, published in Human Vaccines & Immunotherapeutics, reports on a preclinical study of an adjuvanted thermoresponsive gel (TRG) presentation of trivalent inactivated poliovirus vaccine to achieve sublingual immunization. This TRG delivery system, which changes from aqueous solution to viscous gel upon contact with the mucosa at body temperature, helps to retain the formulation at the site of delivery and has functional adjuvant activity from the inclusion of the double-mutant heat-labile toxin (dmLT). The results from this study provide proof-of-concept for sublingual immunization using this delivery system, comprising a TRG and dmLT adjuvant.

Author: White JA, Blum JS, Hosken NA, et al.

Published: 2014

» Visit web page (English)

(Located at www.tandfonline.com)

Citation: White JA, Blum JS, Hosken NA, et al. Serum and Mucosal Antibody Responses to Inactivated Polio Vaccine After Sublingual Immunization Using a Thermoresponsive Gel Delivery System. Human Vaccines & Immunotherapeutics. 2014;10(12):3611-3621.

Resource types: Peer-reviewed journal

Diseases/vaccines: Polio

Topics: Disease/vaccine specific information, Delivery technologies

Regions: Global