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Conservation and Immunogenicity of Novel Antigens in Diverse Isolates of Enterotoxigenic Escherichia coli

This article, published in PLoS Neglected Tropical Diseases, reports on a study that aimed to identify protective antigens shared by many enterotoxigenic Escherichia coli (ETEC) strains to help inform the development of new vaccine candidates. Using a variety of molecular methods, the authors examined a large collection of ETEC isolates for the production of the following novel molecular antigens: EtpA, EatA, YghJ, and EaeH. The resulting data suggest that these novel antigens could significantly complement current approaches and foster improved strategies for the development of broadly protective ETEC vaccines.

Author: Luo Q, Qadri F, Kansal R, Rasko DA, Sheikh A, Fleckenstein JM

Published: 2015

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(Located at journals.plos.org)

Citation: Luo Q, Qadri F, Kansal R, Rasko DA, Sheikh A, Fleckenstein JM. Conservation and Immunogenicity of Novel Antigens in Diverse Isolates of Enterotoxigenic Escherichia coli. PLoS Neglected Tropical Diseases. 2015;9(1):e0003446.

Resource types: Peer-reviewed journal

Diseases/vaccines: Shigellosis and enterotoxigenic Escherichia coli (ETEC)

Topics: Disease/vaccine specific information

Regions: Global