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Reactogenicity and Immunogenicity of Inactivated Poliovirus Vaccine Produced From Sabin Strains: A Phase I Trial in Healthy Adults in Cuba

This article, published in Vaccine, examines the reactogenicity and immunogenicity of two Sabin formulations for inactivated poliovirus vaccine (IPV), non-adjuvanted and adjuvanted, compared with Salk IPV in healthy male adults in Cuba. The results showed that both Sabin IPV formulations were well tolerated and immunogenic against all poliovirus serotypes, suggesting that they could be an alternative to Salk IPV in developing countries, including tropical settings.

Author: Resik S, Tejeda A, Fonseca M, et al.

Published: 2014

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(Located at www.sciencedirect.com)

Citation: Resik S, Tejeda A, Fonseca M, et al. Reactogenicity and Immunogenicity of Inactivated Poliovirus Vaccine Produced From Sabin Strains: A Phase I Trial in Healthy Adults in Cuba. Vaccine. 2014;32(42):5399-5404.

Resource types: Peer-reviewed journal

Diseases/vaccines: Polio

Topics: Vaccine safety and performance, Disease/vaccine specific information

Regions: Latin America and the Caribbean