A Live Attenuated Influenza A(H5N1) Vaccine Induces Long-Term Immunity in the Absence of a Primary Antibody Response

This article, published in The Journal of Infectious Diseases, reports on a study on whether two influenza A(H5N1) live attenuated vaccines for pandemic use (pLAIVs) primed or established long-lasting immunity that could be detected by administration of inactivated subvirion influenza A(H5N1) vaccine (ISIV). The authors found that ISIV administration unmasked long-lasting immunity in influenza A(H5N1) pLAIV recipients, with a rapid, high-titer, high-quality antibody response that was broadly cross-reactive across several influenza A(H5N1) clades.

Author(s): Talaat KR, Luke CJ, Khurana S, et al.

Published: 2014

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    (Located at jid.oxfordjournals.org)

    Citation: Talaat KR, Luke CJ, Khurana S, et al. A Live Attenuated Influenza A(H5N1) Vaccine Induces Long-Term Immunity in the Absence of a Primary Antibody Response. The Journal of Infectious Diseases. Early online publication.