Estimation of the Potential Overall Impact of Human Papillomavirus Vaccination on Cervical Cancer Cases and Deaths

This article, published in Vaccine, reports on a study that aimed to estimate the potential real-life impact of the AS04-adjuvanted HPV-16/18 vaccine on cervical cancer cases and deaths at the country level. The authors found that HPV vaccination could prevent a substantial number of cervical cancer cases and deaths in countries worldwide, with associated cost-offsets due to reduced cervical cancer treatment. Cross-protection increased the estimated potential number of cervical cancer cases and deaths prevented by 34 and 18 percent in Africa and Oceania, respectively. Moreover, vaccination could result in a substantial reduction in the number of high-grade precancerous lesions and associated costs.

Author(s): Van Kriekinge G, Castellsagué X, Cibula D, Demarteau N

Published: 2014

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    Citation: Van Kriekinge G, Castellsagué X, Cibula D, Demarteau N. Estimation of the Potential Overall Impact of Human Papillomavirus Vaccination on Cervical Cancer Cases and Deaths. Vaccine. 2014;32(6):733-739.