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Efficacy of the HPV-16/18 AS04-Adjuvanted Vaccine Against Low-Risk HPV Types (PATRICIA Randomized Trial): An Unexpected Observation

This article, published in the Journal of Infectious Diseases, reports on a post hoc analysis of the Phase 3 PATRICIA (PApilloma TRIal against Cancer In young Adults) trial that was performed to ascertain whether protection against low-risk human papillomavirus (HPV) types was apparent after immunization with the HPV-16/18 AS04-adjuvanted vaccine. The authors conclude that the vaccine appears to have moderate efficacy against persistent infections with a number of low-risk HPV types (HPV-6/11/74), which are responsible for the majority of external genital warts. Antibody and cell-mediated immune response to HPV-6/11 have also recently been observed.

Author: Szarewski A, Skinner SR, Garland SM, et al.

Published: 2013

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(Located at www.ncbi.nlm.nih.gov)

Citation: Szarewski A, Skinner SR, Garland SM, et al. Efficacy of the HPV-16/18 AS04-Adjuvanted Vaccine Against Low-Risk HPV Types (PATRICIA Randomized Trial): An Unexpected Observation. Journal of Infectious Diseases. 2013;208(9):1391-1396.

Resource types: Peer-reviewed journal

Diseases/vaccines: Human papillomavirus (HPV)

Topics: Vaccine safety and performance, Disease/vaccine specific information

Regions: North America and Europe