Intussusception Risk after Rotavirus Vaccination in U.S. Infants
This article, published in the New England Journal of Medicine, reports on a study about the potential increased risk of intussusception after rotavirus vaccination with RotaTeq (RV5, a pentavalent vaccine) and Rotarix (RV1, a monovalent vaccine) among infants in the United States. The results indicated that RV5 was associated with approximately 1.5 excess cases of intussusception per 100,000 recipients of the first dose. The results of the primary analysis for RV1 were not significant, but the secondary analysis suggested a potential risk of intussusception, although the study of RV1 was underpowered. ABSTRACT ONLY. (Learn how users in developing countries can gain free access to journal articles.)
Author(s): Yih WK, Lieu TA, Kulldorff M, et al.
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Citation: Yih WK, Lieu TA, Kulldorff M, et al. Intussusception Risk after Rotavirus Vaccination in U.S. Infants. New England Journal of Medicine. 2014;370(6):503-512.