Rapid Disappearance of Haemophilus influenzae type b Meningitis After Routine Childhood Immunization with Conjugate Vaccines

This study, published in The Lancet, carried out a retrospective survey of the incidence of Hib meningitis over five decades in the Greater Helsinki area of Finland, where all children with bacterial meningitis are treated in one of three centers. In the first five years of the Hib vaccination program the number of cases of Hib meningitis in children aged 0 to 4 years fell sharply, from 30 in 1986 (the first year of the program) to none in 1991. The decline contrasts sharply with the rising trend up to the mid 1980s. Vaccination seems to be the only explanation for the observed change in the epidemiology of Hib meningitis. ABSTRACT ONLY. (Learn how users in developing countries can gain free access to journal articles.)

Author(s): Peltola H, Kilpi T, Anttila M

Published: 1992

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    Citation: Peltola H, Kilpi T, Anttila M. Rapid Disappearance of Haemophilus influenzae type b Meningitis After Routine Childhood Immunization with Conjugate Vaccines. Lancet. 1992;340(8819)592-594.