Development of a Fast-Dissolving Tablet Formulation of a Live Attenuated Enterotoxigenic E. coli Vaccine Candidate
A fast-dissolving tablet (FDT) that could be packaged in a compact stackable blister sheet is a potentially attractive option for formulating oral vaccines, since it would minimally impact the cold chain and could potentially be administered directly to patients without reconstitution. This article, published in Vaccine, reports on a study that used one component of a live attenuated trivalent vaccine under development to produce an FDT for the prevention of diarrhea induced by enterotoxigenic Escherichia coli (ETEC). Study results indicate that the FDT produced by freeze drying directly in a blister sheet could be a practical option for formulating ETEC vaccines for oral immunization and help to facilitate delivery of lifesaving vaccines, particularly in low-resource settings.
Author: Lal M, Priddy S, Bourgeois L, et al.
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Citation: Lal M, Priddy S, Bourgeois L, et al. Development of a Fast-Dissolving Tablet Formulation of a Live Attenuated Enterotoxigenic E. coli Vaccine Candidate. Vaccine. 2013;31(42):4759-4764.
Resource types: Peer-reviewed journal
Diseases/vaccines: Shigellosis and enterotoxigenic Escherichia coli (ETEC)