Conjugate Vaccines and the Carriage of Haemophilus influenzae type b
Many junior doctors today have not had occasion to treat a child for Hib disease. The remarkable absence of cases of this disease is due to the use of conjugate vaccines. In countries with established Hib vaccination programs the incidence of disease has declined sharply. In fact, in some countries protection provided by Hib conjugate vaccines appears to extend to unvacinated infants in the population. This phenomenon has been attributed to the conjugate vaccines' effect of decreasing Hib colonization; however, few controlled studies have been conducted in this area and many aspects of the Hib conjugate vaccines' influence on carriage remain speculative. This review, published in Emerging Infectious Diseases, explores Hib carriage in the context of current efforts at elucidating the effect of conjugate vaccines on Hib within human mucosae.
Author(s): Barbour M
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Citation: Barbour M. Conjugate Vaccines and the Carriage of Haemophilus influenzae type b. Emerging Infectious Diseases. 1996;2(3):176-182.