Protecting the Herd: The Remarkable Effectiveness of the Bacterial Meningitis Polysaccharide-Protein Conjugate Vaccines in Altering Transmission Dynamics

The polysaccharide-protein conjugate vaccines against the pathogens responsible for bacterial meningitis have demonstrated remarkable effectiveness, far beyond the predicted individual efficacy. Approximately half of the effectiveness of these vaccines in preventing disease is due to altering the human-to-human transmission dynamics of these pathogens, leading to herd immunity. The author of this article, published in Transactions of the American Clinical and Climatological Association, reviews how these unanticipated successes are influencing vaccine implementation strategies and the duration of protection, and comments on the immune basis and the effects of these vaccines on pathogen biology.

Author(s): Stephens DS

Published: 2011

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    Citation: Stephens DS. Protecting the Herd: The Remarkable Effectiveness of the Bacterial Meningitis Polysaccharide-Protein Conjugate Vaccines in Altering Transmission Dynamics. Transactions of the American Clinical and Climatological Association. 2011;122:115–123.