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The Impact of Protein-Conjugate Polysaccharide Vaccines: An Endgame for Meningitis?

The impact of conjugate polysaccharide vaccines on disease is largely due to their effectiveness against asymptomatic carriage of bacteria. This reduces transmission, resulting in herd immunity; however, the effect on carriage can result in the evolution of virulent vaccine escape variants. This article, published in the Philosophical Transactions of the Royal Society, Series B: Biological Sciences, examines these phenomena from a biological perspective, using the conjugate meningococcal vaccines as examples. It illustrates how knowledge of the biology and natural history of these bacteria is central to the effective use of these vaccines.

Author: Maiden MCJ

Published: 2013

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(Located at www.ncbi.nlm.nih.gov)

Citation: Maiden MCJ. The Impact of Protein-Conjugate Polysaccharide Vaccines: An Endgame for Meningitis? Philosophical Transactions of the Royal Society, Series B: Biological Sciences. 2013;368(1623):20120147

Resource types: Peer-reviewed journal

Diseases/vaccines: Haemophilus influenzae type b (Hib), Meningococcus, Pneumococcus

Topics: Vaccine safety and performance, Disease/vaccine specific information

Regions: Global