Pneumolysin is a protein toxin produced by virtually all invasive strains of S. pneumoniae and is considered an important virulence factor. It is immunogenic and has the potential to be a new vaccine antigen offering broad serotype-independent coverage protecting against pneumococcal disease. This article, published in the Journal of Pharmaceutical Sciences, provides preformulation characterization results of a recombinant pneumolysin mutant (pneumolysoid L460D), information useful for the development of a stable pneumolysin mutant-based pneumococcal vaccine. ABSTRACT ONLY. (Learn how users in developing countries can gain free access to journal articles.)

Author(s): Hu L, Joshi SB, Liyanage MR, et al.

Published: 2013

Resource types: Peer-reviewed journal

Diseases: Pneumococcus

Topics: Disease/vaccine specific information

Regions: Global