Immune Responses and Protection in Children in Developing Countries Induced by Oral Vaccines

Oral mucosal vaccines have great promise for generating protective immunity against intestinal infections for the benefit of large numbers of people especially young children. However, these vaccines are not equally immunogenic nor protective in different populations, especially among young children in developing-country settings. The reasons for this are not completely understood and may differ by age group. This review, published in Vaccine, aims to summarize the information available on lowered immune responses to mucosal vaccines (such as those against enterotoxigenic Escherichia coli, Shigella, rotavirus, and polio) and on interventions that may help address the constraints of these vaccines when they are used for children living under the greatest stress and under harmful adverse circumstances. ABSTRACT ONLY. (Learn how users in developing countries can gain free access to journal articles.)

Author(s): Qadri F, Bhuiyan TR, Sack DA, Svennerholm A-M

Published: 2013

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    Citation: Qadri F, Bhuiyan TR, Sack DA, Svennerholm A-M. Immune Responses and Protection in Children in Developing Countries Induced by Oral Vaccines. Vaccine. 2013;31(3):452-460.