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Broadening the Age Restriction for Initiating Rotavirus Vaccination in Regions With High Rotavirus Mortality: Benefits of Mortality Reduction Versus Risk of Fatal Intussusception

This article, published in Vaccine, reports on a study that assessed the potential benefits of mortality reduction versus the risk of fatal intussusception when (a) the first dose of rotavirus vaccine was administered by 12 weeks of age compared with (b) an approach that extends age restrictions to allow administration before 1 year of age. The authors found that the additional lives saved in developing countries through broadened age restrictions would far outnumber hypothetical excess intussusception deaths. ABSTRACT ONLY. (Learn how users in developing countries can gain free access to journal articles.)

Author: Patel MM, Clark AD, Glass RI, et al.

Published: 2009

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(Located at www.sciencedirect.com)

Citation: Patel MM, Clark AD, Glass RI, et al. Broadening the Age Restriction for Initiating Rotavirus Vaccination in Regions With High Rotavirus Mortality: Benefits of Mortality Reduction Versus Risk of Fatal Intussusception. Vaccine. 2009;27(22):2916-2922.

Resource types: Peer-reviewed journal

Diseases/vaccines: Rotavirus

Topics: Vaccine safety and performance, Disease/vaccine specific information

Regions: Global