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Pneumococcal Genome Sequencing Tracks a Vaccine Escape Variant Formed Through a Multi-Fragment Recombination Event

This article, published in Nature Genetics, describes a study using array-based sequencing of 62 isolates from a US national monitoring program to study five independent instances of vaccine escape recombination. The study observations clarify the roles of recombination and selection in the population genomics of pneumococcus and provide proof of principle of the considerable value of combining genomic and epidemiological information in the surveillance and enhanced understanding of infectious diseases. ABSTRACT ONLY: (Learn how users in developing countries can gain free access to journal articles.)

Author: Golubchik T, Brueggemann AB, Street T, et al.

Published: 2012

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(Located at www.nature.com)

Citation: Golubchik T, Brueggemann AB, Street T, et al. Pneumococcal Genome Sequencing Tracks a Vaccine Escape Variant Formed Through a Multi-Fragment Recombination Event. Nature Genetics. 2012;44:352-355.

Resource types: Peer-reviewed journal

Diseases/vaccines: Pneumococcus

Topics: Disease/vaccine specific information

Regions: North America and Europe