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Dissociation Between Serum Neutralizing and Glycoprotein Antibody Responses of Infants and Children Who Received Inactivated Respiratory Syncytial Virus Vaccine

In the 1960s a respiratory syncytial virus (RSV) vaccine was evaluated in infants and young children. Vaccinees who received formalin-inactivated RSV during early infancy developed more serious lower-respiratory-tract disease when infected with the virus than did individuals who received formalin-inactivated parainfluenza virus vaccine. This article, published in the Journal of Clinical Microbiology provides a comparison of the humoral immune responses of infants and children to immunization with RSV vaccine. This analysis is helpful for understanding the mechanism(s) underlying the enhancement of disease following infection by the virus. ABSTRACT ONLY. (Learn how users in developing countries can gain free access to journal articles.)

Author: Murphy BR, Prince GA, Walsh EE, et al.

Published: 1986

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(Located at jcm.asm.org)

Citation: Murphy BR, Prince GA, Walsh EE, et al. Dissociation Between Serum Neutralizing and Glycoprotein Antibody Responses of Infants and Children Who Received Inactivated Respiratory Syncytial Virus Vaccine. Journal of Clinical Microbiology. 1986;24(2):197-202.

Resource types: Peer-reviewed journal

Diseases/vaccines: Respiratory syncytial virus (RSV)

Topics: Disease/vaccine specific information

Regions: Global