Vaccine-Enhanced Respiratory Syncytial Virus Disease in Cotton Rats Following Immunization with Lot 100 or a Newly Prepared Reference Vaccine

A formalin-inactivated respiratory syncytial virus vaccine was used to immunize infants in the mid-1960s; when these children later were naturally infected by the virus they developed markedly accentuated disease, and two died. For the present work, the authors of this article, published in Journal of General Virology, prepared a new batch of vaccine using the original formula. Administration of either the old or new vaccines resulted in enhanced lesions in immunized cotton rats subsequently challenged with live virus, although administration of the vaccine reduced virus replication by 90 percent. The authors conclude that the newly prepared vaccine appears suitable as a reference standard for studying the mechanism of vaccine-enhanced disease caused by this virus. ABSTRACT ONLY. (Learn how users in developing countries can gain free access to journal articles.) 

Author(s): Prince GA, Curtis SJ, Yim KC, Porter DD

Published: 2001

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    Citation: Prince GACurtis SJYim KCPorter DD. Vaccine-Enhanced Respiratory Syncytial Virus Disease in Cotton Rats Following Immunization With Lot 100 or a Newly Prepared Reference Vaccine. Journal of General Virology. 2001;82:28812888.