PATH | VRL
Menu

Enhanced Pulmonary Histopathology is Observed in Cotton Rats Immunized with Formalin-Inactivated Respiratory Syncytial Virus (RSV) or Purified F Glycoprotein and Challenged With RSV 3-6 Months After Immunization

The authors of this study, published in Vaccine, compared formalin-inactivated (FI) RSV, purified F glycoprotein in alum, and RSV infection (intranasal) for their immunogenicity, efficacy, and ability to enhance pulmonary histopathology during RSV infection three and six months following immunization by the intramuscular route. The results suggest that the immune response of cotton rats to immunoaffinity purified F glycoprotein can result in enhanced bronchiolar and alveolar histopathology following RSV challenge. Thus, caution should be exercised in studies in humans using a purified F glycoprotein subunit vaccine. ABSTRACT ONLY. (Learn how users in developing countries can gain free access to journal articles.)

Author: Murphy BR, Sotnikov AV, Lawrence LA, Banks SM, Prince GA

Published: 1990

» Visit web page (English)

(Located at www.sciencedirect.com)

Citation: Murphy BR, Sotnikov AV, Lawrence LA, Banks SM, Prince GA. Enhanced Pulmonary Histopathology is Observed in Cotton Rats Immunized with Formalin-Inactivated Respiratory Syncytial Virus (RSV) or Purified F Glycoprotein and Challenged With RSV 3-6 Months After Immunization. Vaccine. 1990;8(5):497–502.  

Resource types: Peer-reviewed journal

Diseases/vaccines: Respiratory syncytial virus (RSV)

Topics: Disease/vaccine specific information

Regions: Global