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Cotton Rats Previously Immunized With a Chimeric RSV FG Glycoprotein Develop Enhanced Pulmonary Pathology When Infected With RSV, a Phenomenon not Encountered Following Immunization With Vaccinia-RSV Recombinants or RSV

In studies conducted in the 1960s, children previously immunized with a formalin-inactivated respiratory syncytial virus (RSV) vaccine (FI-RSV) developed a greater incidence and severity of pulmonary disease during subsequent natural RSV infection than did controls. It was previously shown that cotton rats immunized with FI-RSV or immunoaffinity-purified fusion (F) glycoprotein developed enhanced pulmonary histopathology following intranasal challenge with RSV. The authors of this article, published in Vaccine, present findings from cotton rat studies looking at the ability of various forms of immunization to provide immunogenicity, efficacy, and the ability to alter the host so that enhanced pulmonary histopathology develops during RSV infections three months after immunization. The resulting data confirm the need for caution in studies involving the administration of RSV subunit vaccines to seronegative humans. ABSTRACT ONLY. (Learn how users in developing countries can gain free access to journal articles.)

Author: Connors M, Collins PL, Firestone CY, et al.

Published: 1992

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Citation: Connors M, Collins PL, Firestone CY, et al. Cotton Rats Previously Immunized With a Chimeric RSV FG Glycoprotein Develop Enhanced Pulmonary Pathology When Infected With RSV, a Phenomenon not Encountered Following Immunization With Vaccinia-RSV Recombinants or RSV. Vaccine. 1992;10(7):475-484.

Resource types: Peer-reviewed journal

Diseases/vaccines: Respiratory syncytial virus (RSV)

Topics: Vaccine safety and performance, Disease/vaccine specific information

Regions: Global