DNA Vaccine Delivery by Densely-Packed and Short Microprojection Arrays to Skin Protects Against Vaginal HSV-2 Challenge

This article, published in Vaccine, reports on a study that investigates the tolerability, immunogenicity, and efficacy of a plasmid DNA vaccine encoding the extracellular domain of gD2 using the Nanopatch™, a recently devised silicon microprojection device. The authors found that the vaccine, delivered using this method, is immunogenic and able to elicit protective immunity in a mouse model of acute lethal vaginal HSV-2 infection. Further, the immunogenicity and efficacy demonstrated, together with the ease of fabrication and application of the Nanopatch™, justify continuing optimization of the device for clinical development. ABSTRACT ONLY. (Learn how users in developing countries can gain free access to journal articles.)

Author(s): Kask AS, Chen X, Marshak JO, et al.

Published: 2010

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    Citation: Kask AS, Chen X, Marshak JO, et al. DNA Vaccine Delivery by Densely-Packed and Short Microprojection Arrays to Skin Protects Against Vaginal HSV-2 Challenge. Vaccine. 2010;28(47):7483-7491.