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Inferior Quantitative and Qualitative Immune Responses to Pneumococcal Conjugate Vaccine in Infants With Nasopharyngeal Colonization by Streptococcus pneumoniae During the Primary Series of Immunization

This study, published in Vaccine, corroborates previous hypotheses that infant nasopharyngeal colonization at any stage before completing the primary series of pneumococcal conjugate vaccine (PCV) was associated with inferior quantitative and qualitative antibody responses to the colonizing-serotype. The authors conclude that ongoing monitoring of the effect of widespread PCV implementation in low-resource settings, with a high acquisition rate of early infant colonization, is warranted to determine whether any targeted strategies to reduce early acquisition of pneumococcal colonization will be required. ABSTRACT ONLY. (Learn how users in developing countries can gain free access to journal articles.)

Author: Madhi SA, Violari A, Klugman KP, et al.

Published: 2011

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Citation: Madhi SA, Violari A, Klugman KP, et al. Inferior Quantitative and Qualitative Immune Responses to Pneumococcal Conjugate Vaccine in Infants With Nasopharyngeal Colonization by Streptococcus pneumoniae During the Primary Series of Immunization. Vaccine. 2011;29(40):6994–7001.

Resource types: Peer-reviewed journal

Diseases/vaccines: Pneumococcus

Topics: Disease/vaccine specific information

Regions: Global