Fractional Doses of Inactivated Poliovirus Vaccine in Oman
This article, published in The New England Journal of Medicine, reports on a clinical trial comparing fractional doses of inactivated poliovirus vaccine administered intradermally with full doses of vaccine given intramuscularly, with respect to immunogenicity and reactogenicity. The vaccine was given to infants in Oman, in an effort to evaluate strategies for making the vaccine affordable for use in developing countries. The results of the study show that the different types of doses induce similar levels of seroconversion but significantly lower titers.
Author(s): Mohammed AJ, AlAwaidy S, Bawikar S, et al.
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Citation: Mohammed AJ, AlAwaidy S, Bawikar S, et al. Fractional Doses of Inactivated Poliovirus Vaccine in Oman. The New England Journal of Medicine. 2010;362(25):2351-2359.