Characterization of the Freeze Sensitivity of a Hepatitis B Vaccine
This article, published in Human Vaccines, reports on a study that aimed to characterize the immediate qualitative changes of hepatitis B vaccine caused by freeze exposure. The vaccine was subjected to freezing temperatures ranging from 0°C to -20°C for up to 3 episodes with durations ranging from 1 hour to 7 days. The vaccine was analyzed for freezing point, particle size distribution, tertiary structure, and in vitro and in vivo potency. Whether or not hepatitis B vaccine freezes was shown to be dependent on an array of factors including temperature, rate of temperature change, duration of exposure, supercooling effects, and vibration.
Author(s): Chen D, Tyagi A, Carpenter J, et al.
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Citation: Chen D, Tyagi A, Carpenter J, et al. Characterization of the Freeze Sensitivity of a Hepatitis B Vaccine. Human Vaccines. 2009;5(1):26-32.