Exposure to Heat and Freezing in the Vaccine Cold Chain in Thailand

Good cold chain practice is essential to maintain full immunogenicity of vaccines. This article, published in Vaccine, reports on a study that aimed to identify the likelihood and extent of exposure to inappropriate temperatures in the vaccine cold chain system in Thailand, and to assess the effects of such exposure on vaccine potency. Hepatitis B vaccine was used as a representative cold-sensitive vaccine, and measles vaccine was used as a representative heat-sensitive vaccine. The authors conclude that in Thailand's cold chain system, freezing is a more significant problem than unduly high temeratures. ABSTRACT ONLY. (Learn how users in developing countries can gain free access to journal articles.)

Author(s): Techathawat S, Varinsathien P, Rasdjarmrearnsook A, Tharmaphornpilas P

Published: 2006

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    Citation: Techathawat S, Varinsathien P, Rasdjarmrearnsook A, Tharmaphornpilas P. Exposure to Heat and Freezing in the Vaccine Cold Chain in Thailand. Vaccine. 2006;25(2007):1328-1333.