Heat-Stable Measles Vaccine Produced by Spray Drying

This article, published in Vaccine, reports on the development of a heat-stable measles vaccine powder using a combination of unique stabilizers and mild spray-drying process conditions. The researchers identified spray drying as the optimal processing method for the preparation of dried vaccine, as it generally resulted in negligible process loss and comparable, if not better, storage stability compared to other processes. Key stabilizers identified during the formulation screening processes were L-arginine, human serum albumin, and a combination of divalent cations. ABSTRACT ONLY. (Learn how users in developing countries can gain free access to journal articles.)

Author(s): Ohtake S, Martin RA, Yee L, et al.

Published: 2010

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    Citation: Ohtake S, Martin RA, Yee L, et al. Heat-Stable Measles Vaccine Produced by Spray Drying. Vaccine. 28(5):1275-1284.