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Respiratory Virus Immunization: A Field Trial of Two Inactivated Respiratory Virus Vaccines; an Aqueous Trivalent Parainfluenza Virus Vaccine and an Alum-Precipitated Respiratory Syncytial Virus Vaccine

This article, published in the American Journal of Epidemiology, describes a field trial conducted to evaluate an inactivated, alum-precipitated respiratory syncytial virus (RSV) vaccine and an aqueous trivalent parainfluenza virus vaccine. Study results showed the parainfluenza vaccine to have failed in providing significant protection against natural disease caused by parainfluenza viruses. Only 47 percent of RSV vaccine recipients showed significant rises in neutralizing antibody. The authors further report the observance of increased incidence of RSV illness requiring hospitalization among vaccinees exposed to natural infection after receiving the vaccine. ABSTRACT ONLY. (Learn how users in developing countries can gain free access to journal articles.)

Author: Fulginiti VA, Eller JJ, Sieber OF, Joyner JW, Minamitani M, Meiklejohn G

Published: 1969

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(Located at aje.oxfordjournals.org)

Citation: Fulginiti VA, Eller JJ, Sieber OF, Joyner JW, Minamitani M, Meiklejohn G. Respiratory Virus Immunization: A Field Trial of Two Inactivated Respiratory Virus Vaccines; an Aqueous Trivalent Parainfluenza Virus Vaccine and an Alum-Precipitated Respiratory Syncytial Virus Vaccine. American Journal of Epidemiology. 1969;89(4):435-448.

Resource types: Peer-reviewed journal

Diseases/vaccines: Respiratory syncytial virus (RSV)

Topics: Vaccine safety and performance, Disease/vaccine specific information

Regions: North America and Europe