An Epidemiologic Study of Altered Clinical Reactivity to Respiratory Syncytial (RS) Virus Infection in Children Previously Vaccinated With an Inactivated RS Virus Vaccine

This article, published in the American Journal of Epidemiology, describes a study that evaluated altered clinical reactivity to a formalin-inactivated respiratory syncytial virus (RSV) vaccine candidate administered to healthy infants and children in Washington, District of Columbia. While no local or systemic vaccine reactions were observed, study results found the vaccine candidate to have failed to offer protection and to have been associated with inducing exaggerated illness to naturally occurring RSV infection in the younger vaccinees. ABSTRACT ONLY. (Learn how users in developing countries can gain free access to journal articles.)

Author(s): Kapikian AZ, Mitchell RH, Chanock RM, Shvedoff RA, Stewart CE

Published: 1969

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    Citation: Kapikian AZ, Mitchell RH, Chanock RM, Shvedoff RA, Stewart CE. An Epidemiologic Study of Altered Clinical Reactivity to Respiratory Syncytial (RS) Virus Infection in Children Previously Vaccinated With an Inactivated RS Virus Vaccine. American Journal of Epidemiology. 1969;89(4):405-421.