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Thermostable Formulations of a Hepatitis B Vaccine and a Meningitis A Polysaccharide Conjugate Vaccine Produced by a Spray-Drying Method

This article, published in the journal Vaccine, reports that employing a spray-drying process to produce glassy state formulations of two common subunit vaccines demonstrates that the production of thermostable vaccines is achievable. The process was tested on recombinant hepatitis B vaccine containing aluminum adjuvant and meningitis A protein-polysaccharide conjugate vaccine. The spray-dried hepatitis B formulations remained stable for at least 24 months at 37°C, and several of the meningitis A formulations were completely stable at temperatures up to 60°C for at least 2 weeks, which is when the test ended. ABSTRACT ONLY. (Learn how users in developing countries can gain free access to journal articles.)

Author: Chen D, Kapre S, Goel A, et al.

Published: 2010

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(Located at www.sciencedirect.com)

Citation: Chen D, Kapre S, Goel A, et al. Thermostable Formulations of a Hepatitis B Vaccine and a Meningitis A Polysaccharide Conjugate Vaccine Produced by a Spray-Drying Method. Vaccine. 2010;28(31):5093-9.

Resource types: Peer-reviewed journal

Diseases/vaccines: Hepatitis B, Meningococcus

Topics: Disease/vaccine specific information, Vaccine stabilization

Regions: Global