This article, published in the journal Vaccine, reports that employing a spray-drying process to produce glassy state formulations of two common subunit vaccines demonstrates that the production of thermostable vaccines is achievable. The process was tested on recombinant hepatitis B vaccine containing aluminum adjuvant and meningitis A protein-polysaccharide conjugate vaccine. The spray-dried hepatitis B formulations remained stable for at least 24 months at 37°C, and several of the meningitis A formulations were completely stable at temperatures up to 60°C for at least 2 weeks, which is when the test ended. ABSTRACT ONLY. (Learn how users in developing countries can gain free access to journal articles.)

Author(s): Chen D, Kapre S, Goel A, et al.

Published: 2010

Resource types: Peer-reviewed journal

Diseases: Hepatitis B; Meningococcus

Topics: Disease/vaccine specific information; Vaccine stabilization

Regions: Global