Intussusception Risk and Health Benefits of Rotavirus Vaccination in Mexico and Brazil
This article, published in The New England Journal of Medicine, assesses the association of the monovalent rotavirus vaccine (RV1) with intussusception after routine immunization of infants in Mexico and Brazil. The authors found that RV1 was associated with a short-term risk of intussusception in approximately 1 of every 51,000 to 68,000 vaccinated infants. The authors shared these findings with the World Health Organization and regulatory agencies in Mexico, Brazil, and the United States. These groups unanimously favored continuing the recommendation that rotavirus vaccination be administered to infants based on the fact that the demonstrated real-world benefits of vaccination far outweigh the potential short-term risk of intussusception associated with the vaccine.
Author(s): Patel MM, López-Collada VR, Bulhões MM, et al.
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Citation: Patel MM, López-Collada VR, Bulhões MM, et al. Intussusception Risk and Health Benefits of Rotavirus Vaccination in Mexico and Brazil. The New England Journal of Medicine. 2011;364(24):2283-2292.