Options for Inactivation, Adjuvant, and Route of Topical Administration of a Killed, Unencapsulated Pneumococcal Whole-Cell Vaccine

This article, published in Clinical and Vaccine Immunology, describes research conducted at Children’s Hospital Boston which showed that killing cells of a noncapsulated strain of Streptococcus pneumoniae with chloroform, tricholorethylene, or beta-propiolactone contributed to the protectiveness of a pneumococcal whole-cell vaccine candidate in preclinical studies.

Author(s): Lu Y-J, Yadav P, Clements JD, et al.

Published: 2010

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    (Located at cvi.asm.org)

    Citation: Lu Y-J, Yadav P, Clements JD, et al. Options for Inactivation, Adjuvant, and Route of Topical Administration of a Killed, Unencapsulated Pneumococcal Whole-Cell Vaccine. Clinical and Vaccine Immunology. 2010;17(6):1005-1012.