This article, published in Cell Host & Microbe, gives an overview of preclinical research showing specific T cell antigens to be strong candidates for a protein subunit vaccine designed to prevent colonization of Streptococcus pneumoniae. The article also describes a proteomic screening method to identify antigens for the development of subunit vaccines against mucosal pathogens. Overall, this research supports the advancement of serotype-independent protein-based pneumococcal vaccines that can be readily affordable for the global population.

Author(s): Moffitt KL, Gierahn TM, Lu Y, et al.

Published: 2011

Resource types: Peer-reviewed journal

Diseases: Pneumococcus

Topics: Disease/vaccine specific information

Regions: Global