TH17-Based Vaccine Design for Prevention of Streptococcus pneumoniae Colonization
This article, published in Cell Host & Microbe, gives an overview of preclinical research showing specific T cell antigens to be strong candidates for a protein subunit vaccine designed to prevent colonization of Streptococcus pneumoniae. The article also describes a proteomic screening method to identify antigens for the development of subunit vaccines against mucosal pathogens. Overall, this research supports the advancement of serotype-independent protein-based pneumococcal vaccines that can be readily affordable for the global population.
Author(s): Moffitt KL, Gierahn TM, Lu Y, et al.
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Citation: Moffitt KL, Gierahn TM, Lu Y, et al. TH17-Based Vaccine Design for Prevention of Streptococcus pneumoniae Colonization. Cell Host & Microbe. 2011;9(2):158-165.