The Promise of Conjugate Vaccines for Africa

This article, published in Vaccine, emphasizes the importance of capsular polysaccharide vaccines for preventing disease caused by Neisseria meningitidis and Streptococcus pneumoniae in Africa, reiterating that these vaccines have been proven safe and effective. Experience with N. meningitidis, Haemophilus influenzae type b (Hib) and S. pneumoniae conjugate vaccines has demonstrated that immunogenicity of polysacharide vaccines can be greatly improved by chemical conjugation to a protein carrier. These vaccines have had a dramatic impact on the incidence of the diseases caused by these bacterial pathogens, but questions remain on the optimal schedules for immunization. The authors call for a review of the evidence to determine how to optimize immunization schedules for these vaccines going forward. ABSTRACT ONLY. (Learn how users in developing countries can gain free access to journal articles.)

Author(s): Kieny MP, LaForce FM

Published: 2007

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    (Located at www.ncbi.nlm.nih.gov)

    Citation: Kieny MP, LaForce FM. The Promise of Conjugate Vaccines for Africa. Vaccine. 2007;25(Suppl 1):A108-A110.