The Epidemiology of Meningococcal Disease and the Impact of Vaccines
Neisseria meningitidis causes meningococcal disease, a severe bacterial infection of the bloodstream or meninges, worldwide. The disease is most common among young children, but the existing polysaccharide vaccines have been sparsely used because they confer limited immunogenicity in this age group. This article, published in the Expert Review of Vaccines, outlines how the introduction of the conjugate serogroup C meningococcal vaccine, which has already changed the epidemiology of the disease in industrialized nations, shows potential for broader control with A, C, Y, and W135 conjugates. Further, the development of vaccines for prevention of serogroup B disease in industrialized nations and serogroup A conjugate vaccines for Africa could lead to global control of meningococcal disease. ABSTRACT ONLY. (Learn how users in developing countries can gain free access to journal articles.)
Author(s): Khatami A, Pollard AJ
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Citation: Khatami A, Pollard AJ. The Epidemiology of Meningococcal Disease and the Impact of Vaccines. Expert Review of Vaccines. 2010;9(3):285-298.