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Efficacy of Pentavalent Rotavirus Vaccine Against Severe Rotavirus Gastroenteritis in Infants in Developing Countries in Asia: A Randomised, Double-Blind, Placebo-Controlled Trial

This article, published in The Lancet, assesses the clinical efficacy of the pentavalent, live oral rotavirus vaccine for the prevention of severe rotavirus gastroenteritis in infants in Bangladesh and Vietnam. Study results demonstrated vaccine efficacy of 48.3 percent against severe disease during nearly two years of follow-up. The authors concluded that the vaccine is safe and efficacious against severe rotavirus gastroenteritis among infants in developing countries in Asia, and the results support the expanded World Health Organization recommendation to promote its global use. ABSTRACT ONLY. (Learn how users in developing countries can gain free access to journal articles.)

Author: Zaman K, Dang DA, Victor JC, et al.

Published: 2010

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(Located at www.thelancet.com)

Citation: Zaman K, Dang DA, Victor JC, et al. Efficacy of Pentavalent Rotavirus Vaccine Against Severe Rotavirus Gastroenteritis in Infants in Developing Countries in Asia: A Randomised, Double-Blind, Placebo-Controlled Trial. The Lancet. 2010:376(9741);568-570.

Resource types: Peer-reviewed journal

Diseases/vaccines: Rotavirus

Topics: Disease/vaccine specific information

Regions: Asia