This article, published in Human Vaccines, provides a review of published data on previous candidate rotavirus vaccines and vaccines in current use, with emphasis on their performance in developed versus developing countries. In developed countries, both first- and second-generation rotavirus vaccines have demonstrated high efficacy against severe rotavirus disease (pooled efficacy = 73% and 85%, respectively). In developing countries, small early trials for the first-generation vaccines failed to provide protection against rotavirus disease (pooled efficacy = 20%), however, trials of the second-generation vaccines yielded substantial improvements in efficacy in developing countries (pooled efficacy of 51%), leading to a global recommendation for rotavirus vaccine introduction by the World Health Organization. ABSTRACT ONLY. (Learn how users in developing countries can gain free access to journal articles.)

Author(s): Jiang V, Jiang B, Tate J, Parashar UD, Patel MM

Published: 2010

Resource types: Peer-reviewed journal

Diseases: Rotavirus

Topics: Disease/vaccine specific information

Regions: Global