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Total results with these characteristics: 66

Topic: Vaccine stabilization and formulation

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Stability of Live Attenuated Rotavirus Vaccine With Selected Preservatives and Primary Containers

This article, published in Vaccine, reports the results of a study to evaluate the feasibility of using preservatives to develop a liquid multi-dose formulation and primary packaging alternatives for orally delivered, liquid rotavirus vaccines. The …

Author: Lal M, Jarrahian C, Zhu C, et al.

Publication date: 2016

Stability of Vaccines – Bridging From Stability Data to Continuous Safety and Efficacy Throughout Shelf Life – An Always Reliable Approach?

This article, published in Biologicals, discusses why stability studies are important tools to reliably ensure that the efficacy and safety of medicinal products remain unchanged from release of drug product until the end of shelf life. The author …

Author: Pfleiderer M

Publication date: 2009

Stabilization of HAC1 Influenza Vaccine by Spray Drying: Formulation Development and Process Scale-Up

This article, published in Pharmaceutical Research, reports on a study that aimed to develop a stable formulation of a recombinant H1N1 influenza hemagglutinin vaccine candidate using spray-drying production. The study results demonstrated the …

Author: Zhu C, Shoji Y, McCray S, et al.

Publication date: 2014

Stabilization of Vaccines: Lessons Learned

This editorial, published in Human Vaccines, explores the key logistical, regulatory, procurement, and policy issues associated with the development and use of temperature-stabilized vaccines. The authors reflect on nearly 8 years of work to …

Author: Kristensen D, Chen D

Publication date: 2010

Stabilizing Influenza Vaccines

If a highly virulent pandemic strain were to emerge in today’s interconnected world, influenza has the potential to kill millions of people, especially in developing countries with limited to no resources for pandemic planning, preparedness, and …

Author: PATH

Publication date: 2013

Stakeholder Perceptions of Pentavalent Vaccine (DTwP-HepB-Hib) in the Uniject™ Injection System

This report discusses stakeholder attitudes towards pentavalent vaccine (which combines five antigens for protection against diphtheria, tetanus, pertussis, hepatitis B, and Haemophilus influenzae type B) in the Uniject™ injection system. The …

Author: PATH, Peruvian Ministry of Health, World Health Organization

Publication date: 2014

A Study of Different Buffers to Maximize Viability of an Oral Shigella Vaccine

Live, oral vaccines against bacterial causes of diarrhea have to be formulated and administered in a way that protects them from the harsh acidic gastric environment. However, little work has been done to evaluate the volume of buffer needed to …

Author: Chandrasekaran L, Lal M, Van De Verg LL, Venkatesan MM

Publication date: 2015

Summary of Vaccine Stability Data

These documents provide stability data as of November 2012 on commonly used, licensed vaccines and stability data as of May 2012 from available data on novel, investigational vaccine formulations. Data are sorted by vaccine in a table format in both …

Author: PATH, Working in Tandem Ltd.

Publication date: 2012

Taking Advantage of the True Heat Stability of Vaccines

This fact sheet describes work that Project Optimize is doing to enable immunization programs to take advantage of the true stability of vaccines by labeling them for use at ambient temperatures in a controlled temperature chain for limited periods …

Author: PATH, World Health Organization

Publication date: 2012

Temperature Sensitivity of Vaccines

This document addresses issues regarding potential exposure of temperature-sensitive vaccines to freezing temperatures and provides updated information on vaccine vial monitors, as well as a discussion of future advances in cold chain technology.

Author: World Health Organization

Publication date: 2006

Thermostable Formulations of a Hepatitis B Vaccine and a Meningitis A Polysaccharide Conjugate Vaccine Produced by a Spray-Drying Method

This article, published in the journal Vaccine, reports that employing a spray-drying process to produce glassy state formulations of two common subunit vaccines demonstrates that the production of thermostable vaccines is achievable. The process …

Author: Chen D, Kapre S, Goel A, et al.

Publication date: 2010

US Department of Defense and PATH: Working Together to Advance Global Health Innovations

This fact sheet describes the partnership between PATH and the US Department of Defense (DoD). It highlights PATH projects—including the development of vaccines against enterotoxigenic Escherichia coli, Shigella, and malaria, along with work on …

Author: PATH

Publication date: 2016

US Department of Health and Human Services and PATH: Partnering to Protect and Improve Global Health

PATH and the US Department of Health and Human Services (HHS) work together to improve global health around the world. This fact sheet highlights PATH projects—including work to develop a thermostable vaccine for H1N1 influenza; ROTAVAC®, a new …

Author: PATH

Publication date: 2014

Use of Vaccines Outside of the Cold Chain: A Literature Review

This review compiles the literature available on the use of vaccines outside of the cold chain. Most of the studies analyzed in this review focus on hepatitis B, except one that examines meningococcal Group C vaccine. Most showed that there are no …

Author: PATH, World Health Organization

Publication date: 2008

Vaccinating Children Beyond the ‘Cold Chain’: Extending the Heat Stability of Vaccines

This issue brief reviews the topic of temperature sensitivity of vaccines and the effects it has on the distribution of vaccines to children in low-resource countries. It explores the cost of vaccination damage, potential heat-stabilizing vaccine …

Author: Médecins Sans Frontières Access Campaign

A Vaccine Cold Chain Freezing Study in PNG Highlights Technology Needs for Hot Climate Countries

Emphasis has long been placed on keeping vaccines cold, with less attention devoted to prevention of vaccine damage from freezing. Published reports and field evidence now demonstrate that freezing of vaccines in the cold chain is commonplace, …

Author: Wirkas T, Toikilik S, Miller N, Morgan C, Clements CJ

Publication date: 2006

Vaccine Innovation Lexicon

This document aims to establish a common vaccine innovation vocabulary to help ensure clarity in communications about innovations applied to vaccine products to increase their programmatic suitability, reduce overall costs, bolster supply security …

Author: PATH, Gavi, the Vaccine Alliance

Publication date: 2016

Vaccine Management and Logistics

This section of the World Health Organization website focuses on vaccine management issues including the cold chain, transport, stock management, and reconstitution of vaccines.

Author: World Health Organization

Vaccine Stabilization

This fact sheet describes PATH's work on vaccine stabilization, including the development of a method to protect vaccines containing an aluminum adjuvant from freeze damage, the identification of a technology to improve the heat stability of certain …

Author: PATH

Publication date: 2012

Vaccine Stabilization: Research, Commercialization, and Potential Impact

This article, published in Vaccine, discusses the challenges of different approaches to developing and producing thermostable vaccines. Topics include the technical feasibility of improving vaccine thermostability and thus vaccine effectiveness …

Author: Kristensen D, Chen D, Cummings R

Publication date: 2011

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