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Total results with these characteristics: 55

Topic: Vaccine stabilization and formulation

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Above Zero: Strategies to Prevent Vaccine Freezing

This four-minute animated video emphasizes the difficulty and importance of maintaining proper temperatures in the vaccine cold chain. The risk of exposing vaccines to freezing temperatures are now known to be significant. These risks can be reduced …

Author: PATH, World Health Organization

Publication date: 2013

Advanced Adjuvants for Novel Vaccines: Expanding Access to Technology in the Fight Against Infectious Disease

This fact sheet describes the positive impact that adjuvants can have on vaccine efficacy and, potentially, immunization program costs. It also describes PATH’s work to expand global access to proprietary and non-proprietary adjuvants as well as …

Author: PATH

Publication date: 2012

Advancing Vaccine Formulations of Importance to Developing Countries Using New and Existing Adjuvant Technologies

The positive impact of adjuvants on vaccination can be functional and practical. A handful of adjuvants are currently licensed for human vaccination, and a number of new adjuvants have reached advanced development stages. However, access to these …

Author: Blum J, Chen D, Cummings R

Publication date: 2012

Assessing the Potency of Oral Polio Vaccine Kept Outside of the Cold Chain During a National Immunization Campaign in Chad

This article, published in Vaccine, reports on a study of the potency of monovalent oral polio vaccine type 3 kept at ambient temperatures during a polio immunization campaign in Chad. The results of the study show that post-campaign laboratory …

Author: Zipursky S, Boualam L, Cheikh DO, et al.

Publication date: 2011

Characterization of a Thermostable Hepatitis B Vaccine Formulation

This article, published in the journal Vaccine, reports on the development of a new hepatitis B vaccine formulation that is stable against repeated freezing at -20°C and is also stable for 12 months at 37°C. The improved stability of this …

Author: Braun LJ, Jezek J, Peterson S, et al.

Publication date: 2009

Characterization of the Freeze Sensitivity of a Hepatitis B Vaccine

This article, published in Human Vaccines, reports on a study that aimed to characterize the immediate qualitative changes of hepatitis B vaccine caused by freeze exposure. The vaccine was subjected to freezing temperatures ranging from 0°C to …

Author: Chen D, Tyagi A, Carpenter J, et al.

Publication date: 2009

The Complex Journey of a Vaccine

This infographic provides a visual description of the complicated route that vaccines follow for manufacturing, formulation, packaging, and distribution, including where quality control testing is completed at each step in the process.

Author: International Federation of Pharmaceutical Manufacturers & Associations

Publication date: 2014

Designing Vaccines for Developing-Country Populations: Ideal Attributes, Delivery Devices, and Presentation Formats

This article, published in Procedia in Vaccinology, discusses the importance of designing vaccines with traits that will minimize complications for immunization programs and increase the likelihood of successful adoption. The article also summarizes …

Author: Kristensen D, Zaffran M

Publication date: 2010

Desirable Attributes of Vaccines for Deployment in Low-Resource Settings

This article, published in the Journal of Pharmaceutical Sciences, discusses the opportunities and challenges associated with developing vaccines with desirable attributes, including enhanced stability and efficient packaging, that can help to …

Author: Chen D, Zehrung D

Publication date: 2013

Developing a Vision for Immunization Supply Systems in 2020: Landscape Analysis Summaries

Facilitated by project Optimize and conducted by a multidisciplinary group of partners, these landscape analyses highlight ongoing work related to five priority areas that comprise the vision for immunization supply systems in 2020. The analyses …

Author: PATH, World Health Organization

Publication date: 2011

Development of a Fast-Dissolving Tablet Formulation of a Live Attenuated Enterotoxigenic E. coli Vaccine Candidate

A fast-dissolving tablet (FDT) that could be packaged in a compact stackable blister sheet is a potentially attractive option for formulating oral vaccines, since it would minimally impact the cold chain and could potentially be administered …

Author: Lal M, Priddy S, Bourgeois L, et al.

Publication date: 2013

Development of a Freeze-Stable Formulation for Vaccines Containing Aluminum Salt Adjuvants

This article, published in Vaccine, describes an approach to minimize reliance on the proper implementation of the cold chain to protect vaccines from freeze-thaw inactivation. By including PEG 300, propylene glycol, or glycerol in a hepatitis B …

Author: Jones Braun L, Tyagi A, Perkins S, et al.

Publication date: 2009

DOD and PATH: Collaborations Enhance Health for the World's Poorest People

This fact sheet describes how PATH and the US Department of Defense (DOD) collaborate to enhance the health of the world’s poorest people and presents a sampling of PATH projects, including work on vaccines to prevent diarrhea and vaccine …

Author: PATH

Publication date: 2012

An Economic Evaluation of Thermostable Vaccines in Cambodia, Ghana, and Bangladesh

This article, published in Vaccine, evaluates the incremental health and programmatic cost impacts of theoretical new vaccine products as compared to the standard vaccine products in multi-dose vials in Cambodia, Ghana, and Bangladesh. The authors …

Author: Levin A, Levin C, Kristensen D, Matthias D

Publication date: 2007

Effects of Freezing on Vaccine Potency: Literature Review

This document provides a literature review of articles about the effects of freezing on vaccine potency of hepatitis B, tetanus toxoid, diphtheria, and pertussis vaccines. Also included is a review of stability data of these vaccines at …

Author: PATH

Publication date: 2003

Freeze-Protection of Aluminum-Adjuvanted Vaccines: PATH Formulation Technology

PATH has developed a low-cost and straightforward approach for protecting aluminum-adjuvanted vaccines from irreversible damage that results from freezing. Many current vaccines of importance to global health contain an aluminum-salt adjuvant (such …

Author: PATH

Publication date: 2014

A Freeze-Stable Formulation for DTwP and DTaP Vaccines

This article, published in Human Vaccines & Immunotherapeutics, reports on a study that examined a freeze-stable formulation of the diphtheria-tetanus-pertussis-whole-cell (DTwP) and acellular (DTaP) vaccines. The authors found that the tested …

Author: Xue H, Yang B, Kristensen DD, Chen D

Publication date: 2014

Freezing Temperatures in the Vaccine Cold Chain: A Systematic Literature Review

This analysis, published in the journal Vaccine, highlights the pervasiveness of accidental freezing across the cold chain and makes recommendations for addressing the problem. ABSTRACT ONLY. (Learn how users in developing countries can gain free …

Author: Matthias DM, Robertson J, Garrison MM, Newland S, Nelson C

Publication date: 2007

Generic Preferred Product Profile (gPPP)

This document provides guidance to the vaccine industry and other vaccine development groups on preferred presentations and packaging for vaccines intended for public‐sector use in developing countries. This generic preferred product profile …

Author: Vaccine Presentation and Packaging Advisory Group

Publication date: 2009

Guidelines on the International Packaging and Shipping of Vaccines

This widely used reference from WHO has been updated according to new developments in vaccine stability, temperature monitoring, and recently pre-qualified vaccines.

Author: World Health Organization

Publication date: 2005

A Heat-Stable Hepatitis B Vaccine Formulation

This article, published in Human Vaccines, discusses a study to develop a formulation of recombinant hepatitis B vaccine with improved stability at elevated temperatures. A new vaccine formulation has the potential to be used outside the cold chain …

Author: Jezek J, Chen D, Watson L, et al.

Publication date: 2009

Heat-Stable Measles Vaccine Produced by Spray Drying

This article, published in Vaccine, reports on the development of a heat-stable measles vaccine powder using a combination of unique stabilizers and mild spray-drying process conditions. The researchers identified spray drying as the optimal …

Author: Ohtake S, Martin RA, Yee L, et al.

Publication date: 2010

Hepatitis B Vaccine Freezing in the Indonesian Cold Chain: Evidence and Solutions

This study, published in the Bulletin of the World Health Organization, aimed to document and characterize freezing temperatures in the Indonesian vaccine cold chain to evaluate the feasibility of changes designed to reduce the occurrence of …

Author: Nelson C, et al

Publication date: 2004

Immunization Safety: A Global Priority

This entire issue of the Bulletin of the World Health Organization is devoted to the topic of immunization safety, including vaccine quality, adverse events reporting, and safety of immunization injections.

Author: World Health Organization

Publication date: 2000

Improving the Reach of Vaccines to Low-Resource Regions, With a Needle-Free Vaccine Delivery Device and Long-Term Thermostabilization

In this article, published in the Journal of Controlled Release, the authors describe how dry-coated microprojections, a needle-free vaccine delivery device, can deliver vaccine to abundant antigen-presenting cells in the skin and induce efficient …

Author: Chen X, Fernando GJP, Crichton ML, et al.

Publication date: 2011

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