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Topic: Presentation and packaging

Total results with these characteristics: 64

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Achieving the Global Vision for Future Immunization Supply and Logistics Systems: Action Plans

These action plans describe specific activities and strategies designed to help achieve the common vision for the future of immunization supply systems developed by the Cold Chain and Logistics Task Force (led by the United Nations Children’s …

Author: World Health Organization, PATH

Published: 2012

Advanced Adjuvants for Novel Vaccines: Expanding Access to Technology in the Fight Against Infectious Disease

This fact sheet describes the positive impact that adjuvants can have on vaccine efficacy and, potentially, immunization program costs. It also describes PATH’s work to expand global access to proprietary and non-proprietary adjuvants as well …

Author: PATH

Published: 2012

Advancing Vaccine Formulations of Importance to Developing Countries Using New and Existing Adjuvant Technologies

The positive impact of adjuvants on vaccination can be functional and practical. A handful of adjuvants are currently licensed for human vaccination, and a number of new adjuvants have reached advanced development stages. However, access to these …

Author: Blum J, Chen D, Cummings R

Published: 2012

Assessing the Potency of Oral Polio Vaccine Kept Outside of the Cold Chain During a National Immunization Campaign in Chad

This article, published in Vaccine, reports on a study of the potency of monovalent oral polio vaccine type 3 kept at ambient temperatures during a polio immunization campaign in Chad. The results of the study show that post-campaign laboratory …

Author: Zipursky S, Boualam L, Cheikh DO, et al.

Published: 2011

Breakeven Analysis for Various Human Papillomavirus Vaccine Presentations in Vietnam and Uganda

This report highlights a study that uses a breakeven cost analysis to compare potential prices, wastage rates, and cold chain requirements for various human papillomavirus vaccine presentations. The results of this study provide insight into …

Author: PATH, World Health Organization

Published: 2010

Characterization of a Thermostable Hepatitis B Vaccine Formulation

This article, published in the journal Vaccine, reports on the development of a new hepatitis B vaccine formulation that is stable against repeated freezing at -20°C and is also stable for 12 months at 37°C. The improved stability of this …

Author: Braun LJ, Jezek J, Peterson S, et al.

Published: 2009

Cold Chain Temperature Monitoring in Vietnam: Monitoring Ambient and Cold Chain Temperatures During Delivery of Human Papillomavirus Vaccine

This report summarizes findings from a temperature-monitoring study that gathered ambient temperature data during human papillomavirus (HPV) vaccine delivery in Vietnam. These data are compared to the known heat stability profile of the HPV vaccine …

Author: PATH, World Health Organization

Published: 2010

The Complex Journey of a Vaccine

This infographic provides a visual description of the complicated route that vaccines follow for manufacturing, formulation, packaging, and distribution, including where quality control testing is completed at each step in the process.

Author: International Federation of Pharmaceutical Manufacturers & Associations

Published: 2014

Coverage, Cost, and Safety Impacts of Primary Container Choice

A single decision on the size and type of a vaccine container can have significant implications on the safety, affordability, and coverage of vaccination in routine and campaign settings. Choosing a single-dose vial instead of a multi-dose container …

Author: International Vaccine Access Center

Published: 2013

Designing Vaccines for Developing-Country Populations: Ideal Attributes, Delivery Devices, and Presentation Formats

This article, published in Procedia in Vaccinology, discusses the importance of designing vaccines with traits that will minimize complications for immunization programs and increase the likelihood of successful adoption. The article also summarizes …

Author: Kristensen D, Zaffran M

Published: 2010

Desirable Attributes of Vaccines for Deployment in Low-Resource Settings

This article, published in the Journal of Pharmaceutical Sciences, discusses the opportunities and challenges associated with developing vaccines with desirable attributes, including enhanced stability and efficient packaging, that can help to …

Author: Chen D, Zehrung D

Published: 2013

Developing a Vision for Immunization Supply Systems in 2020: Landscape Analysis Summaries

Facilitated by project Optimize and conducted by a multidisciplinary group of partners, these landscape analyses highlight ongoing work related to five priority areas that comprise the vision for immunization supply systems in 2020. The analyses …

Author: PATH, World Health Organization

Published: 2011

Development of a Fast-Dissolving Tablet Formulation of a Live Attenuated Enterotoxigenic E. coli Vaccine Candidate

A fast-dissolving tablet (FDT) that could be packaged in a compact stackable blister sheet is a potentially attractive option for formulating oral vaccines, since it would minimally impact the cold chain and could potentially be administered …

Author: Lal M, Priddy S, Bourgeois L, et al.

Published: 2013

An Economic Evaluation of Thermostable Vaccines in Cambodia, Ghana, and Bangladesh

This article, published in Vaccine, evaluates the incremental health and programmatic cost impacts of theoretical new vaccine products as compared to the standard vaccine products in multi-dose vials in Cambodia, Ghana, and Bangladesh. The authors …

Author: Levin A, Levin C, Kristensen D, Matthias D

Published: 2007

Effectively Introducing a New Meningococcal A Conjugate Vaccine in Africa: The Burkina Faso Experience

In 2010, Burkina Faso conducted a country-wide campaign to introduce a new Group A meningococcal conjugate vaccine, MenAfriVac™. Leading up to this effort, the following challenges were successfully managed: (1) conducting a large safety study …

Author: Djingarey MH, Barry R, Bonkoungou M, et al.

Published: 2012

Effects of Freezing on Vaccine Potency: Literature Review

This document provides a literature review of articles about the effects of freezing on vaccine potency of hepatitis B, tetanus toxoid, diphtheria, and pertussis vaccines. Also included is a review of stability data of these vaccines at …

Author: PATH

Published: 2003

Evaluation of Out-of-the-cold-chain Approaches for Improving On-time Delivery of the Hepatitis B Birth Dose in Rural Areas of China

This document summarizes the results of a study of out-of-the-cold-chain approaches for improving on-time delivery of birth doses of the hepatitis B vaccine in rural areas of China. The study concluded that this is a safe and effective way to …

Author: PATH

Published: 2005

Evidence of Vaccine Freezing in the Cold Chain: Literature Review

This document provides a literature review of articles about evidence of vaccine freezing in the cold chain. The document is part of a series that describes the serious risk of freezing vaccines and World Health Organization-recommended …

Author: PATH

Published: 2003

Exposure to Heat and Freezing in the Vaccine Cold Chain in Thailand

Good cold chain practice is essential to maintain full immunogenicity of vaccines. This article, published in Vaccine, reports on a study that aimed to identify the likelihood and extent of exposure to inappropriate temperatures in the vaccine cold …

Author: Techathawat S, Varinsathien P, Rasdjarmrearnsook A, Tharmaphornpilas P

Published: 2006

Freezing Temperatures in the Vaccine Cold Chain: A Systematic Literature Review

This analysis, published in the journal Vaccine, highlights the pervasiveness of accidental freezing across the cold chain and makes recommendations for addressing the problem. ABSTRACT ONLY. (Learn how users in developing countries can gain free …

Author: Matthias DM, Robertson J, Garrison MM, Newland S, Nelson C

Published: 2007

Generic Preferred Product Profile (gPPP)

This document provides guidance to the vaccine industry and other vaccine development groups on preferred presentations and packaging for vaccines intended for public‐sector use in developing countries. This generic preferred product profile …

Author: Vaccine Presentation and Packaging Advisory Group

Published: 2009

Getting Started With Vaccine Vial Monitors: Questions and Answers on Field Operations

This excellent, comprehensive training manual addresses and answers important questions about using vaccine vial monitors in the field.

Author: World Health Organization

Published: 2002

Giving Immunizations

This handout provides basic information about giving immunizations, and lists resources and organizations relevant to this topic.

Author: Optimize (PATH, World Health Organization)

Published: 2013

Giving Safe Injections: Using Auto-Disable Syringes for Immunization

This excellent, 112-page manual is a training curriculum for health care workers who provide injections. It includes information on the health impact of unsafe injections, selecting safe and effective vaccines, reconsituting vaccines safely, reading …

Author: PATH

Published: 2001

Guidelines on the International Packaging and Shipping of Vaccines

This widely used reference from WHO has been updated according to new developments in vaccine stability, temperature monitoring, and recently pre-qualified vaccines.

Author: World Health Organization

Published: 2005

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