Topic: Delivery technologies
Total results with these characteristics: 42
- Access to Vaccine Technologies in Developing Countries: Brazil and India
The authors of this study, published in the journal Vaccine, analyzed advantages and disadvantages of different ways vaccine manufacturers access new technologies. Among the methods considered were collaborations with academia and research …
Author: Milstien J, Gaule G, Kaddar M
- Best Infection Control Practices for Interdermal, Subcutaneous, and Intramuscular Needle Injections
From the Bulletin of the World Health Organization, this article discusses evidence-based guidelines for making injections safer. Abstracts are available in Spanish, French, and Arabic.
Author: Hutin Y, Hauri A, Chiarello L, et al.
- Clinical Performance and Safety of the ID Adapter, a Prototype Intradermal Delivery Technology for Vaccines, Drugs, and Diagnostic Tests
The authors of this article, published in Procedia in Vaccinology, discuss a Phase 1 clinical study conducted to evaluate the intradermal (ID) adapter, a prototype intradermal delivery aid, for safety and precision of injection. The authors present …
Author: Jarrahian C, Zehrung D, Saxon E, Griswold E, Klaff L
- The Cure That Kills
This paper examines the health risks posed by unsafe injections in Africa and outlines some of the programs that are helping reduce these risks.
Author: Practical Patient Care
- Designing Vaccines for Developing-Country Populations: Ideal Attributes, Delivery Devices, and Presentation Formats
This article, published in Procedia in Vaccinology, discusses the importance of designing vaccines with traits that will minimize complications for immunization programs and increase the likelihood of successful adoption. The article also summarizes …
Author: Kristensen D, Zaffran M
- Desirable Attributes of Vaccines for Deployment in Low-Resource Settings
This article, published in the Journal of Pharmaceutical Sciences, discusses the opportunities and challenges associated with developing vaccines with desirable attributes, including enhanced stability and efficient packaging, that can help to …
Author: Chen D, Zehrung D
- Development of a Fast-Dissolving Tablet Formulation of a Live Attenuated Enterotoxigenic E. coli Vaccine Candidate
A fast-dissolving tablet (FDT) that could be packaged in a compact stackable blister sheet is a potentially attractive option for formulating oral vaccines, since it would minimally impact the cold chain and could potentially be administered …
Author: Lal M, Priddy S, Bourgeois L, et al.
- Disposable-Syringe Jet Injectors
Jet injectors deliver vaccines and medicines without using needles. PATH has worked with several disposable-syringe jet injector developers to advance designs that are suitable and affordable for routine and campaign immunization programs in …
- DNA Vaccine Delivery by Densely-Packed and Short Microprojection Arrays to Skin Protects Against Vaginal HSV-2 Challenge
This article, published in Vaccine, reports on a study that investigates the tolerability, immunogenicity, and efficacy of a plasmid DNA vaccine encoding the extracellular domain of gD2 using the Nanopatch™, a recently devised silicon …
Author: Kask AS, Chen X, Marshak JO, et al.
- Giving Safe Injections: Using Auto-Disable Syringes for Immunization
This excellent, 112-page manual is a training curriculum for health care workers who provide injections. It includes information on the health impact of unsafe injections, selecting safe and effective vaccines, reconsituting vaccines safely, reading …
- Guidelines for National Strategies for the Safe and Appropriate Use of Injections
This two-page document summarizes key elements to assist in the development of a national strategy for ensuring safe and appropriate use of injections.
Author: World Health Organization
- Improving the Affordability of Inactivated Poliovirus Vaccines (IPV) for Use in Low- and Middle-Income Countries: An Economic Analysis of Strategies to Reduce the Cost of Routine IPV Immunization
This report presents results from an economic model that calculates the costs involved in delivering IPV vaccine in Indian immunization clinics according to three strategies: (1) intradermal delivery of reduced volumes of vaccine per dose, (2) use …
Author: PATH, Working in Tandem, Ltd.
- Improving the Reach of Vaccines to Low-Resource Regions, With a Needle-Free Vaccine Delivery Device and Long-Term Thermostabilization
In this article, published in the Journal of Controlled Release, the authors describe how dry-coated microprojections, a needle-free vaccine delivery device, can deliver vaccine to abundant antigen-presenting cells in the skin and induce efficient …
Author: Chen X, Fernando GJP, Crichton ML, et al.
- Incremental Costs of Introducing Jet Injection Technology for Delivery of Routine Childhood Vaccinations: Comparative Analysis From Brazil, India, and South Africa
This article, published in Vaccine, describes a study that estimated the incremental costs of transitioning from needles and syringes to delivering childhood vaccines with disposable-syringe jet injectors (DSJIs) in Brazil, India, and South Africa. …
Author: Griffiths UK, Santos AC, Nundy N, Jacoby E, Matthias D
- Innovating to Improve Health: PATH Develops and Delivers Novel Solutions for Those Who Need Them Most
This fact sheet provides an overview of PATH's work to develop and deliver innovative health solutions for those who need them most. These solutions range from developing and introducing affordable, appropriate technologies to creating conditions …
- Intradermal Delivery for Vaccine Dose Sparing: Overview of Current Issues
Preclinical and clinical data highlight potential benefits from intradermal delivery of reduced doses of vaccines, possibly using novel delivery devices. This article, published in Vaccine, outlines evidence gaps and logistical challenges of this …
Author: Zehrung D, Jarrahian C, Wales A
- Intradermal Delivery of Vaccines: A Review of the Literature and the Potential for Development for Use in Low- and Middle-Income Countries
The purpose of this report is: (1) to summarize the clinical evidence supporting the intradermal route for vaccine administration and the devices being developed for this purpose; (2) to determine whether intradermal delivery broadly holds promise …
- Intradermal Delivery of Vaccines: Potential Benefits and Current Challenges
This article, published in the Bulletin of the World Health Organization, explores the ways by which the delivery of vaccine antigens to the dermis and/or epidermis layers of the skin (i.e., intradermal vaccine delivery) might be more efficient than …
Author: Hickling JK, Jones KR, Friede M, Zehrung D, Chen D, Kristensen D
- Intranasal Delivery Devices
Intranasal delivery devices deliver vaccines or medications directly to the nasal cavity or lungs, where they can be absorbed directly by the appropriate tissues. This fact sheet describes PATH's work on intranasal delivery devices to administer …
- Landscape Analysis: Trends in Vaccine Availability and Novel Vaccine Delivery Technologies: 2008–2025
This landscape analysis identifies trends in the availability of vaccines and novel vaccine delivery technologies that are and will be of relevance to low- and middle-income countries from the present through 2025.
Author: PATH, World Health Organization
- Microneedle Patches
PATH is exploring ways to address some of the many factors that can prevent people from accessing the vaccines that they need. One potential solution is intradermal delivery of vaccines. Microneedles are a diverse category of delivery technologies …
- Mucosal Immunization Technologies
PATH developed a mucosal immunization technology platform--viable in two formats--that builds on several proven formulation, adjuvant, and delivery technologies that enable the efficient sublingual administration of subunit vaccines. Part of PATH's …
- Optimal Intramuscular Needle-Penetration Depth
The US Centers for Disease Control and Prevention has needle-length recommendations for intramuscular vaccinations in the thigh and shoulder on the basis of the age of the child. Underpenetration of the intramuscular layer with short needles …
Author: Lippert WC, Wall E
The Op.ti.mize e-newsletter is a quarterly publication that highlights advances and innovations in health care logistics, technologies, and policy. Developed by Project Optimize, a collaboration between the World Health Organization and PATH, this …
Author: PATH, World Health Organization
- Oral Delivery Technologies
Vaccines against some pathogens can be more efficacious when delivered by the oral route, particularly if these are the routes of infection. This fact sheet describes PATH's approach to technologies for the oral delivery of vaccines and their …