This series of fact sheets describes symptoms of infection as well as the benefits and risk of vaccination for 14 diseases, including hepatitis B, Haemophilus influenzae type b, influenza, pneumococcal disease, polio, and rotavirus. There …

In the 1960s a respiratory syncytial virus (RSV) vaccine was evaluated in infants and young children. Vaccinees who received formalin-inactivated RSV during early infancy developed more serious lower-respiratory-tract disease when infected with the …

This article, published in Vaccine, reports on an analysis that combines the results of a country-level model of rotavirus vaccination published elsewhere with data from Demographic and Health Surveys on within-country patterns of vaccine coverage …

This article, published in Vaccine, reports on a study that investigates the tolerability, immunogenicity, and efficacy of a plasmid DNA vaccine encoding the extracellular domain of gD2 using the Nanopatch™, a recently devised silicon …

This article, published in the Journal of Medical Microbiology, provide results that show that DNA vaccines expressing PspA are able to elicit protection levels comparable to recombinant protein, even though total anti-PspA IgG response is …

This article warns of the danger of not vaccinating children in light of lower awareness of the consequences of diseases that can be prevented through immunization.

This fact sheet describes how PATH and the US Department of Defense (DOD) collaborate to enhance the health of the world’s poorest people and presents a sampling of PATH projects, including work on vaccines to prevent diarrhea and vaccine …

This 87-page document identifies literature and web resources on costing, cost-benefit analyses, financing, and policy among other issues.

This online exhibition showcases rare books and historical documents dealing with immunization, with a focus on Edward Jenner's role in the discovery of vaccination. His research was based on careful case studies and clinical observation more than a …

Published in the Pediatric Infectious Disease Journal, this article examines whether the use of a pneumococcal conjugate vaccine could reduce the occurrence of respiratory infections and the ensuing antibiotic drug use in the day care. In this …

Published in the journal Pediatrics, this article assess the effect of combined pneumococcal conjugate and polysaccharide vaccinations on the recurrence of otitis media through a randomised, controlled trial.

This article, published in The Lancet, focuses on the three most common causes of acute bacterial meningitis: Haemophilus influenzae, Streptococcus pneumoniae, and Neisseria meningitidis. The authors compare patterns of meningitis attributable to …

The Effective Vaccine Management (EVM) initiative provides materials and tools needed to monitor and assess vaccine supply chains and help countries to improve their supply chain performance. This web page provides links to EVM background and …

This document provides a literature review of articles about the effects of freezing on vaccine potency of hepatitis B, tetanus toxoid, diphtheria, and pertussis vaccines. Also included is a review of stability data of …

This study, published in the New England Journal of Medicine, enrolled 1662 infants in a randomized, double-blind efficacy trial of a heptavalent pneumococcal polysaccharide conjugate vaccine in which the carrier protein is the nontoxic …

Pneumococcal conjugate vaccines have shown a high degree of success in preventing pneumococcal bacteraemia in children. They also reduce the acquisition of carriage of vaccine serotypes in the nasopharynx, and reduce otitis media caused by those …

This study, published in the Journal of Infectious Diseases, determined that the Rotarix® vaccine produced by GlaxoSmithKline decreased the incidence severe gastroenteritis caused by rotavirus at comparable rates among well-nourished and …

This article provides a comprehensive overview of the disease.

This chapter from an annual report explores why licensure of the vaccine against human papillomavirus (HPV) presents the AIDS vaccine field with new opportunities. The report discusses how to advocate for financing commitments to ensure widespread …

The authors of this study, published in Vaccine, compared formalin-inactivated (FI) RSV, purified F glycoprotein in alum, and RSV infection (intranasal) for their immunogenicity, efficacy, and ability to enhance pulmonary histopathology during RSV …

This article, published in the Bulletin of the World Health Organization, describes avenues for service delivery of human papillomavirus (HPV) vaccines and critical information gaps that must be bridged in order to inform future sexual and …

According to this article published in the eJournal Innovation Strategies Today, product development partnerships (PDPs) are generating an increasing flow of health products, including vaccines, for diseases prevalent in developing countries. …

This web page provides information in enteric diseases, including NIAID-supported research, meeting summaries, news releases, and resources for researchers.

Published in the journal Vaccine, this article discusses the importance of creating reliable, long-term demand for the next generation of enteric vaccines, including new rotavirus, Shigella, and ETEC vaccines and priorities for achieving this …

Enteric infections, with or without overt diarrhea, have profound effects on intestinal absorption, nutrition, and childhood development as well as on global mortality. Oral rehydration therapy has reduced the number of deaths from dehydration …