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Region: Global

Total results with these characteristics: 982

Development and Clinical Evaluation of Prevnar 13, a 13-Valent Pneumocococcal CRM197 Conjugate Vaccine

This article, published in the Annals of the New York Academy of Sciences, discusses the development, clinical evaluation, and postlicensure impact of the 13-valent pneumococcal CRM(197) protein conjugate vaccine, PCV13, (Prevnar 13®). ABSTRACT …

Author: Gruber WC, Scott DA, Emini EA

Published: 2012

Development and Preclinical Evaluation of Safety and Immunogenicity of an Oral ETEC Vaccine Containing Inactivated E. coli Bacteria Overexpressing Colonization Factors CFA/I, CS3, CS5 and CS6 Combined With a Hybrid LT/CT B Subunit Antigen, Administered Alone and Together With dmLT Adjuvant

This article, published in Vaccine, describes the development and preclinical testing of new oral vaccine against enterotoxigenic Escherichia coli (ETEC) administered alone and in combination with an adjuvant. The studies found that oral …

Author: Holmgren J, Bourgeois L, Carlin N, et al.

Published: 2013

Development and Technology Transfer of Haemophilus influenzae type b Conjugate Vaccines for Developing Countries

This article, published in Vaccine, describes the development of a Haemophilus influenzae type b (Hib) conjugate vaccine at the National Institute for Public Health and the Environment/Netherlands Vaccine Institute (RIVM/NVI), and the subsequent …

Author: Beurret M, Hamidi A, Kreeftenberg H

Published: 2012

Development of a Fast-Dissolving Tablet Formulation of a Live Attenuated Enterotoxigenic E. coli Vaccine Candidate

A fast-dissolving tablet (FDT) that could be packaged in a compact stackable blister sheet is a potentially attractive option for formulating oral vaccines, since it would minimally impact the cold chain and could potentially be administered …

Author: Lal M, Priddy S, Bourgeois L, et al.

Published: 2013

Development of a Freeze-Stable Formulation for Vaccines Containing Aluminum Salt Adjuvants

This article, published in Vaccine, describes an approach to minimize reliance on the proper implementation of the cold chain to protect vaccines from freeze-thaw inactivation. By including PEG 300, propylene glycol, or glycerol in a hepatitis B …

Author: Jones Braun L, Tyagi A, Perkins S, et al.

Published: 2009

Development of a Humanized Monoclonal Antibody (MEDI-493) With Potent In Vitro and In Vivo Activity Against Respiratory Syncytial Virus

This article, published in The Journal of Infectious Diseases, details a preclinical study evaluating the ability of a humanized monoclonal antibody, MEDI-493 (later named palivizumab and marketed at Synagis®), to recognize a conserved …

Author: Johnson S, Oliver C, Prince GA, et al.

Published: 1997

Development of a Low-Dose Challenge Model for Evaluation of Vaccines for Enterotoxigenic E. coli (ETEC) in Volunteers

This presentation from the Vaccines for Enteric Diseases conference provides results from a clinical trial that found the human challenge model currently being used to test vaccines against enterotoxigenic Escherichia coli (ETEC) is utilizing a …

Author: Harro C, DeNearing B, Marcum A, et al.

Published: 2009

Development of Antibodies Against the Putative Proteinase Maturation Protein A in Relation to Pneumococcal Carriage and Otitis Media

Published in FEMS Immunology and Medical Microbiology, this article examines serum anti-pneumococcal proteinase maturation protein A antibodies at 6, 12, 18 and 24 months of age, and showed that the age-related development of antipneumococcal …

Author: Bogaert D, Holmlund E, Lahdenkari M, et al.

Published: 2006

Development of Lactococcal GEM-Based Pneumococcal Vaccines

Published in the journal Vaccine, this article reports on the development of a novel protein-based nasal vaccine against Streptococcus pneumoniae, in which three pneumococcal proteins were displayed on the surface of a non-recombinant, killed …

Author: Audouy S, van Selm S, van Roosmalen M, et al.

Published: 2007

The Development of Live, Attenuated Rotavirus Vaccines: A Manufacturer's Resource Guide

This guide is a compilation of publicly available information about the manufacturing process of rotavirus vaccines, and aims to provide a resource for manufacturers interested in developing and registering an attenuated, oral rotavirus vaccine. …

Author: PATH, GAVI Alliance

Published: 2006

Development of Strategies to Overcome Barriers to Effective Mucosal Immunization of Infants in Developing Countries

This issue of the Old Herborn University Seminar Monograph provides a summary of the discussions at an expert workshop hosted by the Old Herborn University Foundation in June 2010. The discussions were held to examine the mechanisms that may …

Author: Heidt PJ, Walker RI, Rusch V, eds.

Published: 2011

Development of Vaccines Against Meningococcal Disease

This article, published in the Lancet, reviews the currently available vaccines against meningococcal disease, as well as research and development efforts toward the development of additional vaccines against the disease. ABSTRACT …

Author: Jódar L, Feavers IM, Salisbury D, Granoff DM

Published: 2002

Diagnostic and Laboratory Testing Aspects of JE

This slide presentation give an overivew of the diagnostic and laboratory testing aspects of JE and can be apdated to fit your audience.

Author: PATH

Published: 2007

Diarrheal Disease: Solutions to Defeat a Global Killer

Diarrheal Disease: Solutions to Defeat a Global Killer presents scientific evidence to support strategies to scale up use of interventions, including safe water, improved sanitation and hygiene, breastfeeding and optimal complementary feeding, …

Author: PATH

Published: 2009

Diarrhoea: Why Children Are Still Dying and What Can Be Done

This joint report from the World Health Organization and the United Nations Children's Fund (UNICEF) focuses attention on the prevention and management of diarrheal diseases. It examines the latest available information on the burden of childhood …

Author: World Health Organization, United Nations Children's Fund

Published: 2009

Direct-Drive Solar Vaccine Refrigerators—A New Choice for Vaccine Storage

This evidence brief developed by project Optimize is directed toward supply chain managers in low- and middle-income countries and provides information about direct-drive solar refrigerators, which may be a good option for vaccine storage in areas …

Author: PATH, World Health Organization

Published: 2013

Directory of Immunization Resources

This web page provides an extensive directory of immunization resources for health care professionals, including information on particular diseases and vaccines, immunization schedules, and frequently asked questions. The resources are gathered from …

Author: Immunization Action Coalition

Disease Control Priorities in Developing Countries, Second Edition

A comprehensive global health examination, this book contributes substantially to global initiatives to improve the health of all peoples by providing a multidisciplinary understanding of fundamental issues and challenges, as well as effective …

Author: Disease Control Priorities Project

Published: 2008

Disease Outbreak News

This web page provides frequently updated information about current disease outbreaks, as well as disease-specific archives of past alerts and links to related resources.

Author: World Health Organization

Diseases and the Vaccines That Prevent Them

This series of fact sheets describes symptoms of infection as well as the benefits and risk of vaccination for 14 diseases, including hepatitis B, Haemophilus influenzae type b, influenza, pneumococcal disease, polio, and rotavirus. There …

Author: US Centers for Disease Control and Prevention

Published: 2011

Disposable-Syringe Jet Injectors

Jet injectors deliver vaccines and medicines without using needles. PATH has worked with several disposable-syringe jet injector developers to advance designs that are suitable and affordable for routine and campaign immunization programs in …

Author: PATH

Published: 2014

Dissociation Between Serum Neutralizing and Glycoprotein Antibody Responses of Infants and Children Who Received Inactivated Respiratory Syncytial Virus Vaccine

In the 1960s a respiratory syncytial virus (RSV) vaccine was evaluated in infants and young children. Vaccinees who received formalin-inactivated RSV during early infancy developed more serious lower-respiratory-tract disease when infected with the …

Author: Murphy BR, Prince GA, Walsh EE, et al.

Published: 1986

Distributional Impact of Rotavirus Vaccination in 25 GAVI Countries: Estimating Disparities in Benefits and Cost-Effectiveness

This article, published in Vaccine, reports on an analysis that combines the results of a country-level model of rotavirus vaccination published elsewhere with data from Demographic and Health Surveys on within-country patterns of vaccine coverage …

Author: Rheingans R, Atherly D, Anderson J

Published: 2012

DNA Vaccine Delivery by Densely-Packed and Short Microprojection Arrays to Skin Protects Against Vaginal HSV-2 Challenge

This article, published in Vaccine, reports on a study that investigates the tolerability, immunogenicity, and efficacy of a plasmid DNA vaccine encoding the extracellular domain of gD2 using the Nanopatch™, a recently devised silicon …

Author: Kask AS, Chen X, Marshak JO, et al.

Published: 2010

DNA Vaccines Expressing Pneumococcal Surface Protein A (PspA) Elicit Protection Levels Comparable to Recombinant Protein

This article, published in the Journal of Medical Microbiology, provide results that show that DNA vaccines expressing PspA are able to elicit protection levels comparable to recombinant protein, even though total anti-PspA IgG response is …

Author: Ferreira DM, Miyaji EN, Oliveira MLS, et al.

Published: 2006