Resource type: Peer-reviewed journal
Total results with these characteristics: 633
- Development of a Fast-Dissolving Tablet Formulation of a Live Attenuated Enterotoxigenic E. coli Vaccine Candidate
A fast-dissolving tablet (FDT) that could be packaged in a compact stackable blister sheet is a potentially attractive option for formulating oral vaccines, since it would minimally impact the cold chain and could potentially be administered …
Author: Lal M, Priddy S, Bourgeois L, et al.
- Development of a Freeze-Stable Formulation for Vaccines Containing Aluminum Salt Adjuvants
This article, published in Vaccine, describes an approach to minimize reliance on the proper implementation of the cold chain to protect vaccines from freeze-thaw inactivation. By including PEG 300, propylene glycol, or glycerol in a hepatitis B …
Author: Jones Braun L, Tyagi A, Perkins S, et al.
- Development of a Group A Meningococcal Conjugate Vaccine, MenAfriVac™
Group A meningococcal disease has been an important public health problem in sub-Saharan Africa for over a century. From 2003 to 2009 a monovalent group A conjugate vaccine, MenAfriVac™, was developed through an innovative public/private …
Author: Frasch C, Preziosi M-P, LaForce FM
- Development of a Humanized Monoclonal Antibody (MEDI-493) With Potent In Vitro and In Vivo Activity Against Respiratory Syncytial Virus
This article, published in The Journal of Infectious Diseases, details a preclinical study evaluating the ability of a humanized monoclonal antibody, MEDI-493 (later named palivizumab and marketed at Synagis®), to recognize a conserved …
Author: Johnson S, Oliver C, Prince GA, et al.
- Development of Antibodies Against the Putative Proteinase Maturation Protein A in Relation to Pneumococcal Carriage and Otitis Media
Published in FEMS Immunology and Medical Microbiology, this article examines serum anti-pneumococcal proteinase maturation protein A antibodies at 6, 12, 18 and 24 months of age, and showed that the age-related development of antipneumococcal …
Author: Bogaert D, Holmlund E, Lahdenkari M, et al.
- Development of Lactococcal GEM-Based Pneumococcal Vaccines
Published in the journal Vaccine, this article reports on the development of a novel protein-based nasal vaccine against Streptococcus pneumoniae, in which three pneumococcal proteins were displayed on the surface of a non-recombinant, killed …
Author: Audouy S, van Selm S, van Roosmalen M, et al.
- Development of Strategies to Overcome Barriers to Effective Mucosal Immunization of Infants in Developing Countries
This issue of the Old Herborn University Seminar Monograph provides a summary of the discussions at an expert workshop hosted by the Old Herborn University Foundation in June 2010. The discussions were held to examine the mechanisms that may …
Author: Heidt PJ, Walker RI, Rusch V, eds.
- Development of Vaccines Against Meningococcal Disease
This article, published in the Lancet, reviews the currently available vaccines against meningococcal disease, as well as research and development efforts toward the development of additional vaccines against the disease. ABSTRACT …
Author: Jódar L, Feavers IM, Salisbury D, Granoff DM
- Diarrhoea-Related Hospitalizations in Children Before and After Implementation of Monovalent Rotavirus Vaccination in Mexico
This article, published in the Bulletin of the World Health Organization, reports on a study that compared the incidence of diarrhea in young children before and after the national introduction of monovalent rotavirus vaccine in Mexico. The results …
Author: Esparza-Aguilar M, Gastañaduy PA, Sánchez-Uribe E, et al.
- Direct and Indirect Effects of Rotavirus Vaccination Upon Childhood Hospitalizations in 3 US Counties, 2006–2009
This article, published in Clinical Infectious Diseases, is about an active, population-based surveillance for rotavirus gastroenteritis hospitalizations in three United States counties to assess the impact of rotavirus vaccines. The study …
Author: Payne DC, Staat MA, Edwards KM, et al.
- Disease Burden Due to Enterotoxigenic Escherichia coli (ETEC) in the First Two Years of Life in an Urban Community in Bangladesh
Published in Infection and Immunity, a cohort of 321 children were followed from birth up to two years to determine the incidence of enterotoxigenic Escherichia coli (ETEC) in Bangladesh. Children with ETEC diarrhea were underweight and stunted …
Author: Qadri F, Saha A, Ahmed T
- Dissociation Between Serum Neutralizing and Glycoprotein Antibody Responses of Infants and Children Who Received Inactivated Respiratory Syncytial Virus Vaccine
In the 1960s a respiratory syncytial virus (RSV) vaccine was evaluated in infants and young children. Vaccinees who received formalin-inactivated RSV during early infancy developed more serious lower-respiratory-tract disease when infected with the …
Author: Murphy BR, Prince GA, Walsh EE, et al.
- Distribution of Rotavirus Genotypes in Europe, 2004-2005: The REVEAL Study
Rotavirus genotypes were identified in several European countries using ELISA tests, and investigators determined that G1–G4 and G9 genotypes were responsible for the majority of cases. Citing these results, the authors suggest that rotavirus …
Author: Van Damme P, Giaquinto C, Maxwell M, Todd P, Van der Wielen M
- Distributional Impact of Rotavirus Vaccination in 25 GAVI Countries: Estimating Disparities in Benefits and Cost-Effectiveness
This article, published in Vaccine, reports on an analysis that combines the results of a country-level model of rotavirus vaccination published elsewhere with data from Demographic and Health Surveys on within-country patterns of vaccine coverage …
Author: Rheingans R, Atherly D, Anderson J
- DNA Vaccine Delivery by Densely-Packed and Short Microprojection Arrays to Skin Protects Against Vaginal HSV-2 Challenge
This article, published in Vaccine, reports on a study that investigates the tolerability, immunogenicity, and efficacy of a plasmid DNA vaccine encoding the extracellular domain of gD2 using the Nanopatch™, a recently devised silicon …
Author: Kask AS, Chen X, Marshak JO, et al.
- DNA Vaccines Expressing Pneumococcal Surface Protein A (PspA) Elicit Protection Levels Comparable to Recombinant Protein
This article, published in the Journal of Medical Microbiology, provide results that show that DNA vaccines expressing PspA are able to elicit protection levels comparable to recombinant protein, even though total anti-PspA IgG response is …
Author: Ferreira DM, Miyaji EN, Oliveira MLS, et al.
- A Dose-Escalation Safety and Immunogenicity Study of Live Attenuated Oral Rotavirus Vaccine 116E in Infants: A Randomized, Double-Blind, Placebo-Controlled Trial
This study, published in the Journal of Infectious Diseases, tested the neonatal rotavirus candidate vaccine 116E in a double-blind, placebo-controlled dose-escalation trial in India. Two doses of the Vero cell-adapted vaccine were evaluated in …
Author: Bhandari N, Sharma P, Taneja S, et al.
- Duration of Protection of Pentavalent Rotavirus Vaccination in Nicaragua
This article, published in Pediatrics, summarizes a case-control study conducted at four hospitals in Nicaragua to evaluate the duration of protection after rotavirus vaccination among eligible infants. The pentavalent rotavirus vaccine …
Author: Patel M, Pedreira C, De Oliveira LH, et al.
- Dynamic Models of Meningococcal Carriage, Disease, and the Impact of Serogroup C Conjugate Vaccination
The authors of this article, published in The American Journal of Epidemiology, use data on immunization with serogroup C meningococcal conjugate vaccines in England and Wales to develop and apply a mathematical model that investigates the …
Author: Trotter CL, Gay NJ, Edmunds WJ
- Early Thimerosal Exposure and Neuropsychological Outcome at 7 and 10 Years
Investigators assessed neurological outcomes by testing more than 1,000 children aged 7 to 10 years and determined that early exposure to mercury from thimerosal-containing vaccines was not associated with deficits in neuropsychological functioning. …
Author: Thompson W, Price C, Goodson B, et al.
- Economic Costs of Rotavirus Gastroenteritis and Cost-Effectiveness of Vaccination in Developing Countries
This article, published in The Journal of Infectious Diseases, evaluated the economic burden of rotavirus and the cost-effectiveness of vaccination from the health care perspective. The authors found that rotavirus vaccination would annually prevent …
Author: Rheingans RD, Antil L, Dreibelbis R, Podewils LJ, Bresee JS, Parashar UD
- Economic Evaluation of Delivering Haemophilus influenzae type b Vaccine in Routine Immunization Services in Kenya
This study, published in Bulletin of the World Health Organization, discusses the introduction of Hib vaccine in Kenya, one of the first nine countries to receive financial support from GAVI for Hib vaccine introduction. The objective of this study …
Author: Oloo Akumu A, Englisha M, Scott JAG, Griffiths UK
- Economic Evaluation of Haemophilus influenzae type b Vaccination in Indonesia: A Cost-Effectiveness Analysis
This paper, published in the Journal of Public Health, evaluates the cost-effectiveness of introducing Hib vaccine in Indonesia as an addition to the country's current DTP–Hepatitis B vaccination program.
Author: Broughton E
- Economic Evaluation of the Routine Childhood Immunization Program in the United States, 2009
This article, published in Pediatrics, presents an economic analysis of the US childhood immunization schedule. The study used population-based vaccination coverage, vaccine efficacy data, historical data on disease incidence before vaccination, and …
Author: Zhou F, Shefer A, Wenger J, et al.
- An Economic Evaluation of Thermostable Vaccines in Cambodia, Ghana, and Bangladesh
This article, published in Vaccine, evaluates the incremental health and programmatic cost impacts of theoretical new vaccine products as compared to the standard vaccine products in multi-dose vials in Cambodia, Ghana, and Bangladesh. The authors …
Author: Levin A, Levin C, Kristensen D, Matthias D