From the journal Tropical Medicine and International Health, this summary of surveillance data from Malaysia reveals seasonal peak incidence, age distribution of JE cases, and effect of the JE immunization program on disease incidence.

Published in the New England Journal of Medicine, this study examined population-based data from the Active Bacterial Core Surveillance of the Centers for Disease Control and Prevention to evaluate changes in the burden of invasive disease, defined …

Published in The Lancet, this article assesses the effect of routine infant immunization with seven-valent pneumococcal conjugate vaccine (PCV7) on rates of all-cause and pneumococcal pneumonia admissions. ABSTRACT ONLY. (Learn how users in …

The epidemiology of meningococcal meningitis in the African meningitis belt is characterized by seasonality, localized epidemics, and epidemic waves. To facilitate research and surveillance, the authors of this article, published in BMC Infectious …

This article, published in Procedia in Vaccinology, discusses the importance of designing vaccines with traits that will minimize complications for immunization programs and increase the likelihood of successful adoption. The article also summarizes …

This article, published in the Journal of Pharmaceutical Sciences, discusses the opportunities and challenges associated with developing vaccines with desirable attributes, including enhanced stability and efficient packaging, that can help to …

This article, published in PLoS Medicine, provides an overview of the development and implementation of a national program for the management of severe and very severe childhood pneumonia in Malawi. Based on a successful delivery model used by the …

This article, published in Vaccine, describes the development of a Haemophilus influenzae type b (Hib) conjugate vaccine at the National Institute for Public Health and the Environment/Netherlands Vaccine Institute (RIVM/NVI), and the subsequent …

This article, published in Vaccine, describes an approach to minimize reliance on the proper implementation of the cold chain to protect vaccines from freeze-thaw inactivation. By including PEG 300, propylene glycol, or glycerol in a hepatitis …

Group A meningococcal disease has been an important public health problem in sub-Saharan Africa for over a century. From 2003 to 2009 a monovalent group A conjugate vaccine, MenAfriVac™, was developed through an innovative public/private …

This article, published in The Journal of Infectious Diseases, details a preclinical study evaluating the ability of a humanized monoclonal antibody, MEDI-493 (later named palivizumab and marketed at Synagis®), to recognize a conserved …

Published in FEMS Immunology and Medical Microbiology, this article examines serum anti-pneumococcal proteinase maturation protein A antibodies at 6, 12, 18 and 24 months of age, and showed that the age-related development of antipneumococcal …

Published in the journal Vaccine, this article reports on the development of a novel protein-based nasal vaccine against Streptococcus pneumoniae, in which three pneumococcal proteins were displayed on the surface of a non-recombinant, killed …

This article, which appeared in the Old Herborn University Seminar Monograph, provides a summary of the discussions at a workshop hosted by the Old Herborn University Foundation in June 2010. The discussions were held to examine the …

This article, published in the Lancet, reviews the currently available vaccines against meningococcal disease, as well as research and development efforts toward the development of additional vaccines against the disease. ABSTRACT …

This article, published in The Lancet, discusses diarrheal disease in children in the developed and developing worlds, prevention and treatment options, and what we can learn from looking at diarrheal disease in developed and …

This article, published in Clinical Infectious Diseases, is about an active, population-based surveillance for rotavirus gastroenteritis hospitalizations in three United States counties to assess the impact of rotavirus vaccines. The study …

Published in Infection and Immunity, a cohort of 321 children were followed from birth up to two years to determine the incidence of enterotoxigenic Escherichia coli (ETEC) in Bangladesh. Children with ETEC diarrhea were underweight and stunted …

In the 1960s a respiratory syncytial virus (RSV) vaccine was evaluated in infants and young children. Vaccinees who received formalin-inactivated RSV during early infancy developed more serious lower-respiratory-tract disease when infected with the …

Rotavirus genotypes were identified in several European countries using ELISA tests, and investigators determined that G1–G4 and G9 genotypes were responsible for the majority of cases. Citing these results, the authors suggest that rotavirus …

This article, published in Vaccine, reports on an analysis that combines the results of a country-level model of rotavirus vaccination published elsewhere with data from Demographic and Health Surveys on within-country patterns of vaccine coverage …

This article, published in Vaccine, reports on a study that investigates the tolerability, immunogenicity, and efficacy of a plasmid DNA vaccine encoding the extracellular domain of gD2 using the Nanopatch™, a recently devised silicon …

This article, published in the Journal of Medical Microbiology, provide results that show that DNA vaccines expressing PspA are able to elicit protection levels comparable to recombinant protein, even though total anti-PspA IgG response is …

This study, published in the Journal of Infectious Diseases, tested the neonatal rotavirus candidate vaccine 116E in a double-blind, placebo-controlled dose-escalation trial in India. Two doses of the Vero cell-adapted vaccine were evaluated in …

This article, published in Pediatrics, summarizes a case-control study conducted at four hospitals in Nicaragua to evaluate the duration of protection after rotavirus vaccination among eligible infants. The pentavalent rotavirus vaccine …