Browse resources

Topic: Vaccine safety and performance

Total results with these characteristics: 214

Immunization Safety: A Global Priority

This entire issue of the Bulletin of the World Health Organization is devoted to the topic of immunization safety, including vaccine quality, adverse events reporting, and safety of immunization injections.

Author: World Health Organization

Published: 2000

Immunization Safety Review: Measles-Mumps-Rubella Vaccine and Autism

The US Centers for Disease Control and Prevention and the US National Institutes of Health recognized the need for an independent group to carefully examine the hypothesized measles-mumps-rubella vaccine and autism link and address other …

Author: Institute of Medicine

Published: 2001

Immunization Safety Review: Vaccinations and Sudden Unexpected Death in Infancy

This report contains results of a review completed by the Immunization Safety Review Committee of epidemiologic evidence on Sudden Unexpected Death in Infancy (SUDI) and neonatal death. The committee found that the evidence did not support a causal …

Author: Institute of Medicine

Published: 2003

Immunization Safety Review: Vaccines and Autism

This eighth and final report of the Immunization Safety Review Committee examines the hypothesis that vaccines, specifically the measles-mumps-rubella vaccine and thimerosal-containing vaccines, are causally associated with autism.

Author: Institute of Medicine

Published: 2004

Immunize Canada

This partnership of nongovernmental, professional, health, consumer, government, and private-sector organizations aims to promote the understanding and use of vaccines recommended by Canada's National Advisory Committee on Immunization. Its goal is …

Author: Immunize Canada

Immunogenicity and Safety of the Quadrivalent Human Papillomavirus Vaccine in HIV-1-Infected Women

This article, published in Clinical Infectious Diseases, shares findings of a trial involving 319 human immunodeficiency virus (HIV)-1-infected women in the United States, Brazil, and South Africa. The trial aimed to determine the immunogenicity …

Author: Kojic EM, Kang M, Cespedes MS, et al.

Published: 2014

Immunogenicity of a Monovalent 2009 Influenza A(H1N1) Vaccine in Infants and Children: A Randomized Trial

This article, published in The Journal of the American Medical Association, details a randomized, observer-blind, age-stratified, parallel group study assessing two doses of an inactivated, split-virus 2009 influenza A(H1N1) vaccine in healthy …

Author: Nolan T, McVernon J, Skeljo M, et al.

Published: 2010

The Impact of 7-Valent Pneumococcal Conjugate Vaccine on Invasive Pneumococcal Disease: A Literature Review

This article, published in Advances in Therapy, describes results from a literature review of 37 articles from Australia, western Europe, and North America reporting impact data on invasive pneumococcal disease (IPD) following the introduction of …

Author: Myint TTH, Madhava H, Balmer P, et al.

Published: 2013

Impact of Pneumococcal Conjugate Vaccines on Nasopharyngeal Carriage and Invasive Disease Among Unvaccinated People: Review of Evidence on Indirect Effects

This article, published in Vaccine, summarizes the evidence for the indirect effect of pneumococcal conjugate vaccine on vaccine-type pneumococcal disease and its correlation with changes in carriage among unvaccinated populations.

Author: Davis SM, Deloria-Knoll M, Kassa HT, O'Brien KL

Published: 2013

The Impact of Protein-Conjugate Polysaccharide Vaccines: An Endgame for Meningitis?

The impact of conjugate polysaccharide vaccines on disease is largely due to their effectiveness against asymptomatic carriage of bacteria. This reduces transmission, resulting in herd immunity; however, the effect on carriage can result in the …

Author: Maiden MCJ

Published: 2013

Impact of Rotavirus Vaccination in Australian Children Below 5 Years of Age: A Database Study

This article, published in Human Vaccines & Immunotherapeutics, reports on a study that compared rotavirus hospitalization rates in children less than five years of age before and after the introduction of the rotavirus vaccine Rotarix® in …

Author: Pendleton A, Galic M, Clarke C, et al.

Published: 2013

Impact of Rotavirus Vaccination in Germany: Rotavirus Surveillance, Hospitalization, Side Effects and Comparison of Vaccines

This article, published in the Pediatric Infectious Disease Journal, examines the impact of national introduction of rotavirus vaccination in Germany. Rotavirus-related hospital admissions of children under one year of age decreased by 60 percent in …

Author: Uhlig U, Kostev K, Schuster V, Koletzko S, Uhlig HH

Published: 2014

Impact of Rotavirus Vaccine on Childhood Diarrheal Hospitalization Following Introduction Into the South African Public Immunization Program

This article, published in the Pediatric Infectious Disease Journal, describes a study in South Africa that demonstrated dramatic decreases in diarrhea-related hospitalizations in infants and young children in both rural and urban settings in the …

Author: Msimang VMY, Page N, Groome MJ, et al.

Published: 2013

Influenza Vaccine for Pregnant Women in Resource-Constrained Countries: A Review of the Evidence to Inform Policy Decisions

While influenza vaccination of pregnant women may be justified on the basis of preventing maternal disease alone, demonstrating additional benefits to the newborn is important to inform policy decisions in areas with limited resources and many …

Author: Ortiz JR, Englund JA, Neuzil KM

Published: 2011

Intussusception After Rotavirus Vaccines Reported to US VAERS, 2006-2012

This article, published in Pediatrics, describes investigators' assessment of intussusception events reported to the Vaccine Adverse Event Reporting System from 2006 through 2012, following the respective introductions of RotaTeq® (Merck & …

Author: Haber P, Patel M, Pan Y, et al.

Published: 2013

Intussusception Following Rotavirus Vaccine Administration: Post-Marketing Surveillance in the National Immunization Program in Australia

This article, published in Vaccine, reports that surveillance conducted following routine rotavirus vaccination in Australia did not find an overall increase in intussusception with use of RotaTeq® (Merck & Co., Inc.) and Rotarix® …

Author: Buttery JP, Danchin MH, Lee KJ, et al.

Published: 2011

Intussusception Risk after Rotavirus Vaccination in U.S. Infants

This article, published in the New England Journal of Medicine, reports on a study about the potential increased risk of intussusception after rotavirus vaccination with RotaTeq (RV5, a pentavalent vaccine) and Rotarix (RV1, a monovalent vaccine) …

Author: Yih WK, Lieu TA, Kulldorff M, et al.

Published: 2014

Intussusception Risk and Health Benefits of Rotavirus Vaccination in Mexico and Brazil

This article, published in The New England Journal of Medicine, assesses the association of the monovalent rotavirus vaccine (RV1) with intussusception after routine immunization of infants in Mexico and Brazil. The authors found that RV1 was …

Author: Patel MM, López-Collada VR, Bulhões MM, et al.

Published: 2011

Investigating Live Attenuated Influenza Vaccine Efficacy in Senegal

This fact sheet describes a Phase 3 clinical study that PATH and its partners are conducting in Senegal to evaluate the clinical efficacy of a seasonal, trivalent live attenuated influenza vaccine (LAIV). By providing evidence on how well this type …

Author: PATH

Published: 2013

IPV Introduction, OPV Withdrawal and Routine Immunization Strengthening

This web page contains the rationale for and resources related to the introduction of inactivated polio vaccine (IPV), withdrawal of oral polio vaccine (OPV), and routine immunization strengthening. It provides five in-depth modules covering issues …

Author: World Health Organization

The Journey of Your Child's Vaccine

This infographic provides an overview of how new vaccines are developed, approved, and manufactured, how they are added to the United States' childhood immunization schedule, and how vaccine safety continues to be monitored after introduction.

Author: US Centers for Disease Control and Prevention

Published: 2013

A Live Attenuated Influenza A(H5N1) Vaccine Induces Long-Term Immunity in the Absence of a Primary Antibody Response

This article, published in The Journal of Infectious Diseases, reports on a study on whether two influenza A(H5N1) live attenuated vaccines for pandemic use (pLAIVs) primed or established long-lasting immunity that could be detected by …

Author: Talaat KR, Luke CJ, Khurana S, et al.

Published: 2014

Long-Term Immunogenicity of Measles Vaccine After Coadministration with Live Attenuated Japanese Encephalitis Vaccine

This follow-up study to PATH's original coadministration trial demonstrated that measles seroprotection rates were still high one year post-vaccination among infants who originally seroconverted for measles.

Author: PATH

Published: 2007

Maternal Immunisation in Developing Countries

This article, published in Vaccine, discusses the benefits and challenges of implementing maternal immunization as a method of preventing infections in the developing world. Specifically, the article discusses the high incidence of pneumococcal …

Author: Greenwood B

Published: 2003

Maternal Immunization Against Viral Disease

This article, published in Vaccine, discusses the advantages and disadvantages of maternal immunization to augment the protective effect of maternal antibody against many viral diseases in the young infant. The authors also present more specific …

Author: Englund J, Glezen WP, Piedra PA

Published: 1998