Browse resources

Topic: Vaccine safety and performance

Total results with these characteristics: 188

Influenza Vaccine for Pregnant Women in Resource-Constrained Countries: A Review of the Evidence to Inform Policy Decisions

While influenza vaccination of pregnant women may be justified on the basis of preventing maternal disease alone, demonstrating additional benefits to the newborn is important to inform policy decisions in areas with limited resources and many …

Author: Ortiz JR, Englund JA, Neuzil KM

Published: 2011

Intussusception After Rotavirus Vaccines Reported to US VAERS, 2006-2012

This article, published in Pediatrics, describes investigators' assessment of intussusception events reported to the Vaccine Adverse Event Reporting System from 2006 through 2012, following the respective introductions of RotaTeq® (Merck & …

Author: Haber P, Patel M, Pan Y, et al.

Published: 2013

Intussusception Following Rotavirus Vaccine Administration: Post-Marketing Surveillance in the National Immunization Program in Australia

This article, published in Vaccine, reports that surveillance conducted following routine rotavirus vaccination in Australia did not find an overall increase in intussusception with use of RotaTeq® (Merck & Co., Inc.) and Rotarix® …

Author: Buttery JP, Danchin MH, Lee KJ, et al.

Published: 2011

Intussusception Risk after Rotavirus Vaccination in U.S. Infants

This article, published in the New England Journal of Medicine, reports on a study about the potential increased risk of intussusception after rotavirus vaccination with RotaTeq (RV5, a pentavalent vaccine) and Rotarix (RV1, a monovalent vaccine) …

Author: Yih WK, Lieu TA, Kulldorff M, et al.

Published: 2014

Intussusception Risk and Health Benefits of Rotavirus Vaccination in Mexico and Brazil

This article, published in The New England Journal of Medicine, assesses the association of the monovalent rotavirus vaccine (RV1) with intussusception after routine immunization of infants in Mexico and Brazil. The authors found that RV1 was …

Author: Patel MM, López-Collada VR, Bulhões MM, et al.

Published: 2011

Investigating Live Attenuated Influenza Vaccine Efficacy in Senegal

This fact sheet describes a Phase 3 clinical study that PATH and its partners are conducting in Senegal to evaluate the clinical efficacy of a seasonal, trivalent live attenuated influenza vaccine (LAIV). By providing evidence on how well this type …

Author: PATH

Published: 2013

The Journey of Your Child's Vaccine

This infographic provides an overview of how new vaccines are developed, approved, and manufactured, how they are added to the United States' childhood immunization schedule, and how vaccine safety continues to be monitored after introduction.

Author: US Centers for Disease Control and Prevention

Published: 2013

A Live Attenuated Influenza A(H5N1) Vaccine Induces Long-Term Immunity in the Absence of a Primary Antibody Response

This article, published in The Journal of Infectious Diseases, reports on a study on whether two influenza A(H5N1) live attenuated vaccines for pandemic use (pLAIVs) primed or established long-lasting immunity that could be detected by …

Author: Talaat KR, Luke CJ, Khurana S, et al.

Published: 2014

Long-Term Immunogenicity of Measles Vaccine After Coadministration with Live Attenuated Japanese Encephalitis Vaccine

This follow-up study to PATH's original coadministration trial demonstrated that measles seroprotection rates were still high one year post-vaccination among infants who originally seroconverted for measles.

Author: PATH

Published: 2007

Maternal Immunisation in Developing Countries

This article, published in Vaccine, discusses the benefits and challenges of implementing maternal immunization as a method of preventing infections in the developing world. Specifically, the article discusses the high incidence of pneumococcal …

Author: Greenwood B

Published: 2003

Maternal Immunization Against Viral Disease

This article, published in Vaccine, discusses the advantages and disadvantages of maternal immunization to augment the protective effect of maternal antibody against many viral diseases in the young infant. The authors also present more specific …

Author: Englund J, Glezen WP, Piedra PA

Published: 1998

Maternal Immunization: US FDA Regulatory Considerations

Vaccination of pregnant women provides important health benefits to both mother and infant, and has been an important disease-prevention strategy in these two groups. However, since pregnant women are usually excluded from participation in clinical …

Author: Gruber MF

Published: 2003

Meeting of the Global Advisory Committee on Vaccine Safety, December 2010: Rotavirus Vaccine and Intussusception

This article, from the Weekly Epidemiological Record, reports on the outcome of a meeting of the World Health Organization's independent, authoritative vaccine safety committee where they reviewed postmarketing surveillance that indicated the …

Author: World Health Organization

Published: 2011

Meningococcal Vaccines: Current Issues and Future Strategies

The authors of this article, published in Drugs, provide an overview of the history and current state of meningococcal vaccines. They also review issues related to the vaccines that still need to be addressed including duration of protection, …

Author: Cohn AC, Harrison LH

Published: 2013

Meningococcal Vaccines: What You Need to Know

This fact sheet provides information on meningococcal vaccines, including who should get the vaccine, vaccine-associated risks, and where you can learn more about meningococcal disease and vaccines.

Author: US Centers for Disease Control and Prevention

Published: 2008

Mercury Levels in Newborns and Infants After Receipt of Thimerosal-Containing Vaccines

This article, published in Pediatrics, reports on a study assessing blood levels and the elimination of ethyl mercury after vaccination of infants with thimerosal-containing vaccines. The authors concluded that the blood half-life of intramuscular …

Author: Pichichero ME, Gentile A, Giglio N, et al.

Published: 2008

Monitoring Adverse Events Following Immunization With a New Conjugate Vaccine Against Group A Meningococcus in Niger, September 2010

In Niger, the introduction campaign of MenAfriVac™, a new conjugate vaccine against Neisseria meningitidis serogroup A, was conducted in the District of Filingue, during September 2010. The authors of this article, published in …

Author: Chaibou MS, Bako H, Salisou L, et al.

Published: 2012

A Multi-Center, Qualitative Assessment of Pediatrician and Maternal Perspectives on Rotavirus Vaccines and the Detection of Porcine circovirus

This article, published in BMC Pediatrics, reports on research that evaluated perceptions among physicians and mothers after the 2011 finding of DNA fragments of Porcine circovirus in rotavirus vaccines. Physicians expressed that the finding was of …

Author: Payne DC, Humiston S, Opel D, et al.

Published: 2011

Neuropsychological Performance 10 Years After Immunization in Infancy With Thimerosal-Containing Vaccines

This study, published in the journal Pediatrics, compares the neuropsychological performance, ten years after vaccination, of two groups of children exposed randomly to different amounts of thimerosal through immunization. The study concludes that, …

Author: Tozzi AE, Bisiacchi P, Tarantino V, et al.

Published: 2009

New Decade of Vaccines

In December 2010, global health leaders committed to making the next 10 years the Decade of Vaccines - to ensure discovery, development, and delivery of lifesaving vaccines globally, especially to the poorest countries. This special series of …

Author: Horton R, ed.

Published: 2011

The Next Decade of Vaccines: Societal and Scientific Challenges

This article, published in The Lancet, aims to provide a deeper understanding of the societal factors that threaten to compromise realization of the public health gains that immunization can achieve in the next decade and beyond. Also discussed are …

Author: Moxon ER, Siegrist CA

Published: 2011

No Vaccine for the Scaremongers

Published in the Bulletin of the World Health Organization, this article discusses anxieties over safety of vaccines and the damage these worries could have on immunization programs.

Author: World Health Organization

Published: 2008

A Novel Influenza A (H1N1) Vaccine in Various Age Groups

This article, published in The New England Journal of Medicine, details a randomized clinical trial conducted in China to evaluate the safety and immunogenicity of a split-virus, inactivated vaccine candidate against the 2009 pandemic …

Author: Zhu F, Wang H, Fang H, et al.

Published: 2009

On-Time Vaccine Receipt in the First Year Does Not Adversely Affect Neuropsychological Outcomes

This article, published in the journal Pediatrics, examines whether children who received recommended vaccines on time during the first year of life had different neuropsychological outcomes at 7 to 10 years of age as compared with children with …

Author: Smith MJ, Woods CR

Published: 2010

Optimum Dosing of Pneumococcal Conjugate Vaccine For Infants: A Landscape Analysis of Evidence Supporting Different Schedules

This supplement of the Pediatric Infectious Disease Journal features nine articles on the considerations for pneumococcal conjugate vaccine (PCV) dosing schedules. This systematic literature review and corresponding analyses support the dosing …

Author: O’Brien KL, Goldblatt D, Whitney CG, eds.

Published: 2014